Cell Biology Antibodies 3

Anti-PCDHGA1 Antibody (CAB13193)

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SKU:
CAB13193
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PCDHGA1 Antibody
Antibody SKU:CAB13193
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-360 of human PCDHGA1 (NP_114382.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-360 of human PCDHGA1 (NP_114382.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PAFT QAQY HINV PENV PLGT QLLM VNAT DPDE GANG EVTY SFHN VDHR VAQI FRLD SYTG EISN KEPL DFEE YKMY SMEV QAQD GAGL MAKV KVLI KVLD VNDN APEV TITS VTTA VPEN F
Gene ID:56114
Uniprot:Q9Y5H4
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:90kDa/101kDa
Observed MW:90kDa
Synonyms:PCDHGA1, PCDH-GAMMA-A1
Background:This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
UniProt Protein Function:PCDHGA1: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Calcium-binding; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 5q31

NCBI Summary:This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5H4
NCBI GenInfo Identifier:37999844
NCBI Gene ID:56114
NCBI Accession:Q9Y5H4.1
UniProt Secondary Accession:Q9Y5H4,Q2M273, Q9Y5D6,
UniProt Related Accession:Q9Y5H4
Molecular Weight:90,160 Da
NCBI Full Name:Protocadherin gamma-A1
NCBI Synonym Full Names:protocadherin gamma subfamily A, 1
NCBI Official Symbol:PCDHGA1  
NCBI Official Synonym Symbols:PCDH-GAMMA-A1  
NCBI Protein Information:protocadherin gamma-A1
UniProt Protein Name:Protocadherin gamma-A1
Protein Family:Protocadherin
UniProt Gene Name:PCDHGA1  
UniProt Entry Name:PCDG1_HUMAN
Anti-PCDHGA1 Antibody (CAB13193)Western blot analysis of extracts of rat lung, using PCDHGA1 antibody (CAB13193) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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