Cell Biology Antibodies 7

Anti-PCDHA10 Antibody (CAB17185)

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SKU:
CAB17185
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PCDHA10 Antibody
Antibody SKU:CAB17185
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human PCDHA10 (NP_114066.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human PCDHA10 (NP_114066.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PRFS VTEQ KLSI PESR LLDS RFPL EGAS DADV GENA LLTY KLSP NEYF VLDI INKK DKDK FPVL VLRK LLDR EENP QLKL L
Gene ID:56139
Uniprot:Q9Y5I2
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:PCDHA10, CNR8, CNRN8, CNRS8, CRNR8, PCDH-ALPHA10
Background:This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
UniProt Protein Function:PCDHA10: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: integral to plasma membrane

Biological Process: cell adhesion; nervous system development

NCBI Summary:This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5I2
NCBI GenInfo Identifier:13878433
NCBI Gene ID:56139
NCBI Accession:Q9Y5I2.1
UniProt Secondary Accession:Q9Y5I2,O75280, Q9NRU2, A1L493,
UniProt Related Accession:Q9Y5I2
Molecular Weight:92,185 Da
NCBI Full Name:Protocadherin alpha-10
NCBI Synonym Full Names:protocadherin alpha 10
NCBI Official Symbol:PCDHA10  
NCBI Official Synonym Symbols:CNR8; CNRN8; CNRS8; CRNR8; PCDH-ALPHA10  
NCBI Protein Information:protocadherin alpha-10
UniProt Protein Name:Protocadherin alpha-10
Protein Family:Protocadherin
UniProt Gene Name:PCDHA10  
UniProt Entry Name:PCDAA_HUMAN
Anti-PCDHA10 Antibody (CAB17185)Western blot analysis of extracts of U-87MG cells, using PCDHA10 antibody (CAB17185) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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