Cell Biology Antibodies 4

Anti-PCDH8 Antibody (CAB14250)

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SKU:
CAB14250
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PCDH8 Antibody
Antibody SKU:CAB14250
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 450-750 of human PCDH8 (NP_002581.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, SH-SY5Y, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 450-750 of human PCDH8 (NP_002581.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VTAA SLDR ERIA EYNL TLVA EDRG APPL RTVR PYTV RVGD ENDN APLF TRPV YEVS VREN NPPG AYLA TVAA RDRD LGRN GQVT YRLL EAEV GRAG GAVS TYVS VDPA TGAI YALR SFDY ETLR QLDV RIQA SDGG SPQL SSSA LVQV RVLD QNDH APVL VHPA PANG SLEV AVPG RTAK DTVV ARVQ ARDA DEGA NGEL AFEL QQQE PREA FAIG RRTG EILL TGDL SQEP PGRV FRAL LVIS DGGR PPLT TTAT VSFV VTAG GGRG PAAP ASAG SPER SRPP GSRL GVSG SVLQ WDTP L
Gene ID:5100
Uniprot:O95206
Cellular Location:Cell junction, Cell membrane, Cell projection, Single-pass type I membrane protein, dendrite, postsynaptic cell membrane, presynaptic cell membrane, synapse
Calculated MW:103kDa/113kDa
Observed MW:113kDa
Synonyms:PCDH8, ARCADLIN, PAPC
Background:This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.
UniProt Code:O95206
NCBI GenInfo Identifier:6631102
NCBI Gene ID:
NCBI Accession:NP_002581
Molecular Weight:
NCBI Full Name:protocadherin-8 isoform 1
UniProt Protein Name:Protocadherin-8
UniProt Synonym Protein Names:Arcadlin
Protein Family:Protocadherin
UniProt Gene Name:PCDH8  
UniProt Entry Name:PCDH8_HUMAN
Anti-PCDH8 Antibody (CAB14250)Western blot analysis of extracts of various cell lines, using PCDH8 antibody (CAB14250) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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