Metabolism Antibodies 3
Anti-PCB Antibody (CAB8980)
- SKU:
- CAB8980
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PCB Antibody |
| Antibody SKU: | CAB8980 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PCB |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse liver, Mouse brain, Mouse kidney, Rat liver |
| Immunogen: | A synthesized peptide derived from human PCB |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5091 |
| Uniprot: | P11498 |
| Cellular Location: | |
| Calculated MW: | 130kDa |
| Observed MW: | 130KDa |
| Synonyms: | PCB |
| Background: | This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | PC: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency). PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia. |
| UniProt Protein Details: | Protein type:EC 6.4.1.1; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Ligase Chromosomal Location of Human Ortholog: 11q13.4-q13.5 Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion Molecular Function:protein binding; pyruvate carboxylase activity Biological Process: biotin metabolic process; gluconeogenesis; viral RNA genome packaging Disease: Pyruvate Carboxylase Deficiency |
| NCBI Summary: | This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11498 |
| NCBI GenInfo Identifier: | 1709947 |
| NCBI Gene ID: | 5091 |
| NCBI Accession: | P11498.2 |
| UniProt Secondary Accession: | P11498,Q16705, B4DN00, |
| UniProt Related Accession: | P11498 |
| Molecular Weight: | 57,925 Da |
| NCBI Full Name: | Pyruvate carboxylase, mitochondrial |
| NCBI Synonym Full Names: | pyruvate carboxylase |
| NCBI Official Symbol: | PC |
| NCBI Official Synonym Symbols: | PCB |
| NCBI Protein Information: | pyruvate carboxylase, mitochondrial |
| UniProt Protein Name: | Pyruvate carboxylase, mitochondrial |
| UniProt Synonym Protein Names: | Pyruvic carboxylase; PCB |
| Protein Family: | PCTP-like protein |
| UniProt Gene Name: | PC |
| UniProt Entry Name: | PYC_HUMAN |
 | Western blot - PCB Rabbit mAb (CAB8980) |
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