Epigenetics & Nuclear Signaling Antibodies 1

Anti-PBX2 Antibody (CAB10233)

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SKU:
CAB10233
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-PBX2 Antibody
Antibody SKU:CAB10233
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 321-430 of human PBX2 (NP_002577.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 321-430 of human PBX2 (NP_002577.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AVSV TQGG HSRT SSPT PPSS AGSG GSFN LSGS GDMF LGMP GLNG DSYS ASQV ESLR HSMG PGGY GDNL GGGQ MYSP REMR ANGS WQEA VTPS SVTS PTEG PGSV HSDT SN
Gene ID:5089
Uniprot:P40425
Cellular Location:Nucleus
Calculated MW:45kDa
Observed MW:55kDa
Synonyms:PBX2, G17, HOX12, PBX2MHC
Background:This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
UniProt Protein Function:PBX2: Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. Belongs to the TALE/PBX homeobox family.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nucleus

Molecular Function:protein binding; transcription factor binding

NCBI Summary:This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
UniProt Code:P40425
NCBI GenInfo Identifier:1352729
NCBI Gene ID:5089
NCBI Accession:P40425.2
UniProt Secondary Accession:P40425,A2BFJ2,
UniProt Related Accession:P40425
Molecular Weight:45,881 Da
NCBI Full Name:Pre-B-cell leukemia transcription factor 2
NCBI Synonym Full Names:PBX homeobox 2
NCBI Official Symbol:PBX2  
NCBI Official Synonym Symbols:G17; HOX12; PBX2MHC  
NCBI Protein Information:pre-B-cell leukemia transcription factor 2
UniProt Protein Name:Pre-B-cell leukemia transcription factor 2
UniProt Synonym Protein Names:Homeobox protein PBX2; Protein G17
Protein Family:Pre-B-cell leukemia transcription factor
UniProt Gene Name:PBX2  
UniProt Entry Name:PBX2_HUMAN
Anti-PBX2 Antibody (CAB10233)Western blot analysis of extracts of various cell lines, using PBX2 antibody (CAB10233) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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