Epigenetics & Nuclear Signaling Antibodies 1
Anti-PBX2 Antibody (CAB10233)
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- SKU:
- CAB10233
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PBX2 Antibody |
| Antibody SKU: | CAB10233 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-430 of human PBX2 (NP_002577.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-430 of human PBX2 (NP_002577.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVSV TQGG HSRT SSPT PPSS AGSG GSFN LSGS GDMF LGMP GLNG DSYS ASQV ESLR HSMG PGGY GDNL GGGQ MYSP REMR ANGS WQEA VTPS SVTS PTEG PGSV HSDT SN |
| Gene ID: | 5089 |
| Uniprot: | P40425 |
| Cellular Location: | Nucleus |
| Calculated MW: | 45kDa |
| Observed MW: | 55kDa |
| Synonyms: | PBX2, G17, HOX12, PBX2MHC |
| Background: | This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. |
| UniProt Protein Function: | PBX2: Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1. Belongs to the TALE/PBX homeobox family. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: nucleus Molecular Function:protein binding; transcription factor binding |
| NCBI Summary: | This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40425 |
| NCBI GenInfo Identifier: | 1352729 |
| NCBI Gene ID: | 5089 |
| NCBI Accession: | P40425.2 |
| UniProt Secondary Accession: | P40425,A2BFJ2, |
| UniProt Related Accession: | P40425 |
| Molecular Weight: | 45,881 Da |
| NCBI Full Name: | Pre-B-cell leukemia transcription factor 2 |
| NCBI Synonym Full Names: | PBX homeobox 2 |
| NCBI Official Symbol: | PBX2 |
| NCBI Official Synonym Symbols: | G17; HOX12; PBX2MHC |
| NCBI Protein Information: | pre-B-cell leukemia transcription factor 2 |
| UniProt Protein Name: | Pre-B-cell leukemia transcription factor 2 |
| UniProt Synonym Protein Names: | Homeobox protein PBX2; Protein G17 |
| Protein Family: | Pre-B-cell leukemia transcription factor |
| UniProt Gene Name: | PBX2 |
| UniProt Entry Name: | PBX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PBX2 antibody (CAB10233) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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