Cell Biology Antibodies 13
Anti-PAXIP1 Antibody (CAB17431)
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- SKU:
- CAB17431
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PAXIP1 Antibody |
| Antibody SKU: | CAB17431 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PAXIP1. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human PAXIP1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 22976 |
| Uniprot: | Q6ZW49 |
| Cellular Location: | Nucleus matrix |
| Calculated MW: | 93kDa/117kDa/121kDa |
| Observed MW: | Refer to figures |
 | Immunohistochemistry - PAXIP1 Rabbit pAb (CAB17431) |
| Synonyms: | PAXIP1, CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2 |
| Background: | This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. |
| UniProt Protein Function: | PAXIP1: Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PA1 to sites of DNA damage and the PA1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL- containing HMT complexes. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 7q36 Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: DNA damage response, signal transduction by p53 class mediator; double-strand break repair via nonhomologous end joining; histone H3-K4 methylation; positive regulation of histone acetylation; positive regulation of histone H3-K36 methylation; positive regulation of histone H3-K4 methylation; positive regulation of isotype switching; positive regulation of protein ubiquitination; response to ionizing radiation Disease: Alzheimer Disease |
| NCBI Summary: | This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6ZW49 |
| NCBI GenInfo Identifier: | 317373316 |
| NCBI Gene ID: | 22976 |
| NCBI Accession: | Q6ZW49.2 |
| UniProt Secondary Accession: | Q6ZW49,O15404, Q6N099, Q6ZWH9, Q7Z315, Q86UN0, Q8N4P9 Q96HP2, |
| UniProt Related Accession: | Q6ZW49 |
| Molecular Weight: | 93,882 Da |
| NCBI Full Name: | PAX-interacting protein 1 |
| NCBI Synonym Full Names: | PAX interacting protein 1 |
| NCBI Official Symbol: | PAXIP1 |
| NCBI Official Synonym Symbols: | PTIP; TNRC2; CAGF28; CAGF29; PACIP1; PAXIP1L |
| NCBI Protein Information: | PAX-interacting protein 1 |
| UniProt Protein Name: | PAX-interacting protein 1 |
| UniProt Synonym Protein Names: | PAX transactivation activation domain-interacting protein |
| Protein Family: | PAX-interacting protein |
| UniProt Gene Name: | PAXIP1 |
| UniProt Entry Name: | PAXI1_HUMAN |
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