Cardiovascular Antibodies

Anti-PAX7 Antibody (CAB4134)

(No reviews yet) Write a Review
SKU:
CAB4134
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PAX7 Antibody
Antibody SKU:CAB4134
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PAX7
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, MCF7, C2C12, U-87MG, Rat brain
Immunogen:A synthesized peptide derived from human PAX7
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5081
Uniprot:P23759
Cellular Location:
Calculated MW:57kDa
Observed MW:57KDa
Synonyms:HUP1, PAX7B, RMS2
Background:This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Protein Function:PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 1p36.13

Molecular Function:transcription factor activity

Biological Process: anatomical structure morphogenesis; negative regulation of apoptosis

Disease: Rhabdomyosarcoma 2

NCBI Summary:This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Code:P23759
NCBI GenInfo Identifier:857434982
NCBI Gene ID:5081
NCBI Accession:P23759.4
UniProt Secondary Accession:P23759,Q0VA99, Q2PJS5, E9PFV9,
UniProt Related Accession:P23759
Molecular Weight:55kDa
NCBI Full Name:Paired box protein Pax-7
NCBI Synonym Full Names:paired box 7
NCBI Official Symbol:PAX7  
NCBI Official Synonym Symbols:HUP1; RMS2; PAX7B  
NCBI Protein Information:paired box protein Pax-7
UniProt Protein Name:Paired box protein Pax-7
UniProt Synonym Protein Names:HuP1
Protein Family:Paired box protein
UniProt Gene Name:PAX7  
Anti-PAX7 Antibody (CAB4134)Western blot - PAX7 Rabbit mAb (CAB4134)
View AllClose

0 Reviews

View AllClose

Related Products