Cardiovascular Antibodies
Anti-PAX7 Antibody (CAB4134)
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- SKU:
- CAB4134
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-PAX7 Antibody |
| Antibody SKU: | CAB4134 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PAX7 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, C2C12, U-87MG, Rat brain |
| Immunogen: | A synthesized peptide derived from human PAX7 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5081 |
| Uniprot: | P23759 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 57KDa |
| Synonyms: | HUP1, PAX7B, RMS2 |
| Background: | This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Protein Function: | PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 1p36.13 Molecular Function:transcription factor activity Biological Process: anatomical structure morphogenesis; negative regulation of apoptosis Disease: Rhabdomyosarcoma 2 |
| NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P23759 |
| NCBI GenInfo Identifier: | 857434982 |
| NCBI Gene ID: | 5081 |
| NCBI Accession: | P23759.4 |
| UniProt Secondary Accession: | P23759,Q0VA99, Q2PJS5, E9PFV9, |
| UniProt Related Accession: | P23759 |
| Molecular Weight: | 55kDa |
| NCBI Full Name: | Paired box protein Pax-7 |
| NCBI Synonym Full Names: | paired box 7 |
| NCBI Official Symbol: | PAX7 |
| NCBI Official Synonym Symbols: | HUP1; RMS2; PAX7B |
| NCBI Protein Information: | paired box protein Pax-7 |
| UniProt Protein Name: | Paired box protein Pax-7 |
| UniProt Synonym Protein Names: | HuP1 |
| Protein Family: | Paired box protein |
| UniProt Gene Name: | PAX7 |
 | Western blot - PAX7 Rabbit mAb (CAB4134) |
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