Immunology Antibodies 3

Anti-PARP9 Antibody (CAB15526)

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SKU:
CAB15526
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-PARP9 Antibody
Antibody SKU:CAB15526
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human PARP9 (NP_001139577.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human PARP9 (NP_001139577.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEIK KETA AEIL FDEV LTFA KDHV KHQL TVKF VIFP TDLE IYKA FSSE MAKR SKML SLNN YSVP QSTR EEKR ENGL EARS PAIN LMGF NVEE MYEA HAWI QRIL SLQN HHII ENNH ILYL GRKE HDIL SQLQ KTSS VSIT EIIS PGRT ELEI EGAR ADLI EVVM NIED MLCK VQEE MARK KERG LWRS LGQW TIQQ QKTQ DEMK ENII FLKC PVPP TQEL LDQK KQFE KCGL QVLK VEKI DNEV LMAA FQRK KKMM EEKL HRQP VSHR LFQQ VPYQ FCNV VCRV GFQR MYST PCDP KYGA G
Gene ID:83666
Uniprot:Q8IXQ6
Cellular Location:Cytoplasm, Nucleus, cytosol
Calculated MW:80kDa/92kDa/96kDa
Observed MW:Refer to figures
Synonyms:PARP9, ARTD9, BAL, BAL1, MGC:7868
Background:
UniProt Protein Function:ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD+-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).
UniProt Code:Q8IXQ6
NCBI GenInfo Identifier:226371710
NCBI Gene ID:83666
NCBI Accession:NP_001139574.1
UniProt Secondary Accession:Q8IXQ6,Q8TCP3, Q9BZL8, Q9BZL9, A8KA94, B2R8S9, E9PFM7
UniProt Related Accession:Q8IXQ6
Molecular Weight:80,291 Da
NCBI Full Name:poly
NCBI Synonym Full Names:poly(ADP-ribose) polymerase family member 9
NCBI Official Symbol:PARP9  
NCBI Official Synonym Symbols:BAL; BAL1; ARTD9; MGC:7868  
NCBI Protein Information:poly [ADP-ribose] polymerase 9
UniProt Protein Name:Poly [ADP-ribose] polymerase 9
UniProt Synonym Protein Names:ADP-ribosyltransferase diphtheria toxin-like 9; ARTD9; B aggressive lymphoma protein
Protein Family:Balbiani ring protein
UniProt Gene Name:PARP9  
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