Immunology Antibodies 3
Anti-PARP9 Antibody (CAB15526)
- SKU:
- CAB15526
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Antibody Name: | Anti-PARP9 Antibody |
Antibody SKU: | CAB15526 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human PARP9 (NP_001139577.1). |
Application: | WB |
Recommended Dilution: | WB 1:200 - 1:2000 |
Reactivity: | Human |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human PARP9 (NP_001139577.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MEIK KETA AEIL FDEV LTFA KDHV KHQL TVKF VIFP TDLE IYKA FSSE MAKR SKML SLNN YSVP QSTR EEKR ENGL EARS PAIN LMGF NVEE MYEA HAWI QRIL SLQN HHII ENNH ILYL GRKE HDIL SQLQ KTSS VSIT EIIS PGRT ELEI EGAR ADLI EVVM NIED MLCK VQEE MARK KERG LWRS LGQW TIQQ QKTQ DEMK ENII FLKC PVPP TQEL LDQK KQFE KCGL QVLK VEKI DNEV LMAA FQRK KKMM EEKL HRQP VSHR LFQQ VPYQ FCNV VCRV GFQR MYST PCDP KYGA G |
Gene ID: | 83666 |
Uniprot: | Q8IXQ6 |
Cellular Location: | Cytoplasm, Nucleus, cytosol |
Calculated MW: | 80kDa/92kDa/96kDa |
Observed MW: | Refer to figures |
Synonyms: | PARP9, ARTD9, BAL, BAL1, MGC:7868 |
Background: |
UniProt Protein Function: | ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD+-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300). |
UniProt Code: | Q8IXQ6 |
NCBI GenInfo Identifier: | 226371710 |
NCBI Gene ID: | 83666 |
NCBI Accession: | NP_001139574.1 |
UniProt Secondary Accession: | Q8IXQ6,Q8TCP3, Q9BZL8, Q9BZL9, A8KA94, B2R8S9, E9PFM7 |
UniProt Related Accession: | Q8IXQ6 |
Molecular Weight: | 80,291 Da |
NCBI Full Name: | poly |
NCBI Synonym Full Names: | poly(ADP-ribose) polymerase family member 9 |
NCBI Official Symbol: | PARP9 |
NCBI Official Synonym Symbols: | BAL; BAL1; ARTD9; MGC:7868 |
NCBI Protein Information: | poly [ADP-ribose] polymerase 9 |
UniProt Protein Name: | Poly [ADP-ribose] polymerase 9 |
UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 9; ARTD9; B aggressive lymphoma protein |
Protein Family: | Balbiani ring protein |
UniProt Gene Name: | PARP9 |
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