Cell Biology Antibodies 4
Anti-PAPSS1 Antibody (CAB13773)
- SKU:
- CAB13773
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-PAPSS1 Antibody |
Antibody SKU: | CAB13773 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-260 of human PAPSS1 (NP_005434.4). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | LO2, HT-29, 293T, Mouse brain, Rat kidney |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-260 of human PAPSS1 (NP_005434.4). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | SEYE KPEA PELV LKTD SCDV NDCV QQVV ELLQ ERDI VPVD ASYE VKEL YVPE NKLH LAKT DAET LPAL KIN |
Gene ID: | 9061 |
Uniprot: | O43252 |
Cellular Location: | |
Calculated MW: | 70kDa |
Observed MW: | 71kDa |
Synonyms: | PAPSS1, ATPSK1, PAPSS, SK1 |
Background: |
UniProt Protein Function: | Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). |
NCBI Summary: | Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008] |
UniProt Code: | O43252 |
NCBI GenInfo Identifier: | 46094058 |
NCBI Gene ID: | 9061 |
NCBI Accession: | NP_005434 |
UniProt Secondary Accession: | O43252,O43841, O75332, Q6IAX6, Q96FB1, Q96TF4, Q9P1P9 Q9UE98, |
UniProt Related Accession: | O43252 |
Molecular Weight: | 70.9 kDa (626aa) |
NCBI Full Name: | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
NCBI Synonym Full Names: | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
NCBI Official Symbol: | PAPSS1 |
NCBI Official Synonym Symbols: | SK1; PAPSS; ATPSK1 |
NCBI Protein Information: | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
UniProt Protein Name: | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 |
UniProt Synonym Protein Names: | 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase |
Protein Family: | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase |
UniProt Gene Name: | PAPSS1 |
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