Cell Biology Antibodies 17

Anti-Pannexin 1 Antibody (CAB5167)

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SKU:
CAB5167

Description

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Antibody Name:Anti-Pannexin 1 Antibody
Antibody SKU:CAB5167
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Pannexin 1
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:C2C12, K-562, U-87MG, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human Pannexin 1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:24145
Uniprot:Q96RD7
Cellular Location:
Calculated MW:48kDa
Observed MW:50KDa
Synonyms:MRS1, PX1, UNQ2529
Background:The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
UniProt Protein Function:PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; plasma membrane; gap junction

Molecular Function:actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; gap junction hemi-channel activity; calcium channel activity; receptor binding

Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; cation transport; response to ATP

NCBI Summary:The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
UniProt Code:Q96RD7
NCBI GenInfo Identifier:317373551
NCBI Gene ID:24145
NCBI Accession:Q96RD7.4
UniProt Secondary Accession:Q96RD7,O75968, Q543A0, Q6UW26, Q96AM9, Q96L77, Q96RS5
UniProt Related Accession:Q96RD7
Molecular Weight:426
NCBI Full Name:Pannexin-1
NCBI Synonym Full Names:pannexin 1
NCBI Official Symbol:PANX1  
NCBI Official Synonym Symbols:PX1; MRS1; UNQ2529  
NCBI Protein Information:pannexin-1; innexin
UniProt Protein Name:Pannexin-1
Protein Family:Pannexin
UniProt Gene Name:PANX1  
UniProt Entry Name:PANX1_HUMAN
Anti-Pannexin 1 Antibody (CAB5167)Western blot - Pannexin 1 Rabbit mAb (CAB5167)
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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