Cell Biology Antibodies 17

Anti-PANK2 Antibody (CAB18502)

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SKU:
CAB18502
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PANK2 Antibody
Antibody SKU:CAB18502
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:80025
Uniprot:Q9BZ23
Cellular Location:
Calculated MW:
Observed MW:63kDa
Anti-PANK2 Antibody (CAB18502)Western blot - PANK2 Rabbit pAb (CAB18502)
Synonyms:C20orf48, HARP, HSS, NBIA1, PKAN, PANK2
Background:
UniProt Protein Function:PANK2: a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported.
UniProt Protein Details:

Protein type:Mitochondrial; Kinase, other; EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: cytoplasm; mitochondrial intermembrane space

Molecular Function:pantothenate kinase activity

Biological Process: coenzyme biosynthetic process; regulation of fatty acid metabolic process

Disease: Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration; Neurodegeneration With Brain Iron Accumulation 1

NCBI Summary:This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZ23
NCBI GenInfo Identifier:118572682
NCBI Gene ID:80025
NCBI Accession:Q9BZ23.3
UniProt Secondary Accession:Q9BZ23,Q5T7I2, Q5T7I4, Q7RTX5, Q8N7Q4, Q8TCR5, Q9BYW5 Q9HAF2, B1AK33, B2Z3X0, D3DVZ0,
UniProt Related Accession:Q9BZ23
Molecular Weight:50,582 Da
NCBI Full Name:Pantothenate kinase 2, mitochondrial
NCBI Synonym Full Names:pantothenate kinase 2
NCBI Official Symbol:PANK2  
NCBI Official Synonym Symbols:HSS; HARP; PKAN; NBIA1; C20orf48  
NCBI Protein Information:pantothenate kinase 2, mitochondrial
UniProt Protein Name:Pantothenate kinase 2, mitochondrial
UniProt Synonym Protein Names:Pantothenic acid kinase 2
Protein Family:Pantothenate kinase
UniProt Gene Name:PANK2  
UniProt Entry Name:PANK2_HUMAN
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