Epigenetics & Nuclear Signaling Antibodies 2
Anti-PAN2 Antibody (CAB15373)
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- SKU:
- CAB15373
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PAN2 Antibody |
| Antibody SKU: | CAB15373 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human PAN2 (NP_001120932.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, NIH/3T3, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human PAN2 (NP_001120932.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DFAQ VLKR SICL DQNT QAWC DTCE KYQP TIQT RNIR HLPD ILVI NCEV NSSK EADF WRMQ AEVA FKMA VKKH GGEI SKNK EFAL ADWK ELGS PEGV LVCP SIEE LKNV WLPF SIRM KMTK NKGL DVCN WTDG DEMQ WGPA RAEE EHGV YVYD LMAT VVHI LDSR TGGS LVAH IKVG ETYH QRKE GVTH QQWY LFND FLIE PIDK HEAV QFDM NWKV PAIL YYVK RNLN SRYN LNIK NPIE ASVL LAEA SLAR KQRK THTT FIPL MLNE MPQI GDLV GLDA EFVT LNEE EAEL RSDG TKST I |
| Gene ID: | 9924 |
| Uniprot: | Q504Q3 |
| Cellular Location: | Cytoplasm, Nucleus, P-body |
| Calculated MW: | 135kDa |
| Observed MW: | 135kDa |
| Synonyms: | PAN2, USP52 |
| Background: | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | USP52: Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein. Belongs to the peptidase C19 family. PAN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ribonuclease; EC 3.1.13.4; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: cytosol Molecular Function:3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; protein binding Biological Process: poly(A) tail shortening |
| NCBI Summary: | This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q504Q3 |
| NCBI GenInfo Identifier: | 296439280 |
| NCBI Gene ID: | 9924 |
| NCBI Accession: | Q504Q3.3 |
| UniProt Secondary Accession: | Q504Q3,O75189, Q76E12, Q8IVE1, |
| UniProt Related Accession: | Q504Q3 |
| Molecular Weight: | 135,281 Da |
| NCBI Full Name: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
| NCBI Synonym Full Names: | PAN2 poly(A) specific ribonuclease subunit |
| NCBI Official Symbol: | PAN2 |
| NCBI Official Synonym Symbols: | USP52 |
| NCBI Protein Information: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
| UniProt Protein Name: | PAB-dependent poly(A)-specific ribonuclease subunit PAN2 |
| UniProt Synonym Protein Names: | Inactive ubiquitin carboxyl-terminal hydrolase 52 |
| Protein Family: | Proteasome-activating nucleotidase |
| UniProt Gene Name: | PAN2 |
| UniProt Entry Name: | PAN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PAN2 antibody (CAB15373) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s. |
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