Immunology Antibodies 2
Anti-PAG1 Antibody (CAB16303)
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- SKU:
- CAB16303
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-PAG1 Antibody |
| Antibody SKU: | CAB16303 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PAG1 (NP_060910.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PAG1 (NP_060910.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CDPE EEAP PPVP VKLL DENE NLQE KEGG EAEE SATD TTSE TNKR FSSL SYKS REED PTLT EEEI SAMY SSVN KPGQ LVNK SGQS LTVP ESTY TSIQ GDPQ R |
| Gene ID: | 55824 |
| Uniprot: | Q9NWQ8 |
| Cellular Location: | |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | PAG1, CBP, PAG |
| Background: | The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. |
| UniProt Protein Function: | PAG: an ubiquitous type III transmembrane adaptor protein that binds to the tyrosine kinase CSK protein. It is thought to be involved in the regulation of T cell activation. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Adaptor/scaffold Chromosomal Location of Human Ortholog: 8q21.13 Cellular Component: plasma membrane; integral to membrane; lipid raft Molecular Function:protein binding; SH3/SH2 adaptor activity; SH2 domain binding Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of signal transduction; signal transduction; negative regulation of T cell activation; T cell receptor signaling pathway; regulation of T cell activation |
| NCBI Summary: | The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NWQ8 |
| NCBI GenInfo Identifier: | 63054864 |
| NCBI Gene ID: | 55824 |
| NCBI Accession: | NP_060910.3 |
| UniProt Secondary Accession: | Q9NWQ8,Q3U1F9, Q9JM80, |
| UniProt Related Accession: | Q9NWQ8 |
| Molecular Weight: | 46,981 Da |
| NCBI Full Name: | phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
| NCBI Synonym Full Names: | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| NCBI Official Symbol: | PAG1 |
| NCBI Official Synonym Symbols: | CBP; PAG |
| NCBI Protein Information: | phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; phosphoprotein associated with glycosphingolipid microdomains 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprot |
| UniProt Protein Name: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
| UniProt Synonym Protein Names: | Csk-binding protein; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp |
| Protein Family: | CBP3-like protein |
| UniProt Gene Name: | PAG1 |
| UniProt Entry Name: | PHAG1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PAG1 antibody (CAB16303) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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