Immunology Antibodies 2

Anti-PAG1 Antibody (CAB16303)

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SKU:
CAB16303
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-PAG1 Antibody
Antibody SKU:CAB16303
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PAG1 (NP_060910.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PAG1 (NP_060910.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CDPE EEAP PPVP VKLL DENE NLQE KEGG EAEE SATD TTSE TNKR FSSL SYKS REED PTLT EEEI SAMY SSVN KPGQ LVNK SGQS LTVP ESTY TSIQ GDPQ R
Gene ID:55824
Uniprot:Q9NWQ8
Cellular Location:
Calculated MW:46kDa
Observed MW:46kDa
Synonyms:PAG1, CBP, PAG
Background:The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
UniProt Protein Function:PAG: an ubiquitous type III transmembrane adaptor protein that binds to the tyrosine kinase CSK protein. It is thought to be involved in the regulation of T cell activation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: plasma membrane; integral to membrane; lipid raft

Molecular Function:protein binding; SH3/SH2 adaptor activity; SH2 domain binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of signal transduction; signal transduction; negative regulation of T cell activation; T cell receptor signaling pathway; regulation of T cell activation

NCBI Summary:The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NWQ8
NCBI GenInfo Identifier:63054864
NCBI Gene ID:55824
NCBI Accession:NP_060910.3
UniProt Secondary Accession:Q9NWQ8,Q3U1F9, Q9JM80,
UniProt Related Accession:Q9NWQ8
Molecular Weight:46,981 Da
NCBI Full Name:phosphoprotein associated with glycosphingolipid-enriched microdomains 1
NCBI Synonym Full Names:phosphoprotein membrane anchor with glycosphingolipid microdomains 1
NCBI Official Symbol:PAG1  
NCBI Official Synonym Symbols:CBP; PAG  
NCBI Protein Information:phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Csk-binding protein; phosphoprotein associated with glycosphingolipid microdomains 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprot
UniProt Protein Name:Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
UniProt Synonym Protein Names:Csk-binding protein; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp
Protein Family:CBP3-like protein
UniProt Gene Name:PAG1  
UniProt Entry Name:PHAG1_HUMAN
Anti-PAG1 Antibody (CAB16303)Western blot analysis of extracts of various cell lines, using PAG1 antibody (CAB16303) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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