Metabolism Antibodies 2
Anti-PAFAH2 Antibody (CAB16941)
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- SKU:
- CAB16941
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PAFAH2 Antibody |
| Antibody SKU: | CAB16941 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-350 of human PAFAH2 (NP_000428.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-350 of human PAFAH2 (NP_000428.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AWMF PLER DFYP KARG PVFF INTE KFQT MESV NLMK KICA QHEQ SRII TVLG SVHR SQTD FAFV TGNL IGKF FSTE TRGS LDPY EGQE VMV |
| Gene ID: | 5051 |
| Uniprot: | Q99487 |
| Cellular Location: | |
| Calculated MW: | 44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | PAFAH2, HSD-PLA2 |
| Background: | This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. |
| UniProt Protein Function: | PAFAH2: Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. Belongs to the serine esterase family. |
| UniProt Protein Details: | Protein type:Hydrolase; Lipid-binding; EC 3.1.1.47; Lipid Metabolism - ether lipid Chromosomal Location of Human Ortholog: 1p36 Molecular Function:phospholipid binding Biological Process: lipid metabolic process |
| NCBI Summary: | This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99487 |
| NCBI GenInfo Identifier: | 6647691 |
| NCBI Gene ID: | 5051 |
| NCBI Accession: | Q99487.1 |
| UniProt Secondary Accession: | Q99487,O15458, Q5SY02, D3DPK1, |
| UniProt Related Accession: | Q99487 |
| Molecular Weight: | 44,036 Da |
| NCBI Full Name: | Platelet-activating factor acetylhydrolase 2, cytoplasmic |
| NCBI Synonym Full Names: | platelet activating factor acetylhydrolase 2 |
| NCBI Official Symbol: | PAFAH2 |
| NCBI Official Synonym Symbols: | HSD-PLA2 |
| NCBI Protein Information: | platelet-activating factor acetylhydrolase 2, cytoplasmic |
| UniProt Protein Name: | Platelet-activating factor acetylhydrolase 2, cytoplasmic |
| UniProt Synonym Protein Names: | Serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2 |
| Protein Family: | Platelet-activating factor acetylhydrolase |
| UniProt Gene Name: | PAFAH2 |
| UniProt Entry Name: | PAFA2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PAFAH2 antibody (CAB16941) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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