Metabolism Antibodies 1
Anti-PAFAH1B2 Antibody (CAB12170)
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- SKU:
- CAB12170
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PAFAH1B2 Antibody |
| Antibody SKU: | CAB12170 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Mouse brain, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-229 of human PAFAH1B2 (NP_002563.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSQG DSNP AAIP HAAE DIQG DDRW MSQH NRFV LDCK DKEP DVLF VGDS MVQL MQQY EIWR ELFS PLHA LNFG IGGD TTRH VLWR LKNG ELEN IKPK VIVV WVGT NNHE NTAE EVAG GIEA IVQL INTR QPQA KIIV LGLL PRGE KPNP LRQK NAKV NQLL KVSL PKLA NVQL LDTD GGFV HSDG AISC HDMF DFLH LTGG GYAK ICKP LHEL IMQL LEET PEEK QTTI A |
| Gene ID: | 5049 |
| Uniprot: | P68402 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 14kDa/17kDa/22kDa/25kDa |
| Observed MW: | 30kDa |
| Synonyms: | PAFAH1B2, HEL-S-303 |
| Background: | Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. |
| UniProt Protein Function: | PAFAH1B2: Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 3.1.1.47; Lipase; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: cytoplasm; cytosol; extracellular region; fibrillar center; nucleolus; plasma membrane Molecular Function:phospholipase A2 activity; platelet-activating factor acetyltransferase activity; protein binding Biological Process: brain development; lipid metabolic process; neutrophil degranulation; positive regulation of macroautophagy |
| NCBI Summary: | Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P68402 |
| NCBI GenInfo Identifier: | 55977294 |
| NCBI Gene ID: | 5049 |
| NCBI Accession: | P68402.1 |
| UniProt Secondary Accession: | P68402,O00687, Q29459, Q6IBR6, A8DPS5, A8DPS6, A8DPS7 E9PEJ5, E9PLP3, |
| UniProt Related Accession: | P68402 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | Platelet-activating factor acetylhydrolase IB subunit beta |
| NCBI Synonym Full Names: | platelet activating factor acetylhydrolase 1b catalytic subunit 2 |
| NCBI Official Symbol: | PAFAH1B2 |
| NCBI Official Synonym Symbols: | HEL-S-303 |
| NCBI Protein Information: | platelet-activating factor acetylhydrolase IB subunit beta |
| UniProt Protein Name: | Platelet-activating factor acetylhydrolase IB subunit beta |
| UniProt Synonym Protein Names: | PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta |
| Protein Family: | Platelet-activating factor acetylhydrolase |
| UniProt Gene Name: | PAFAH1B2 |
 | Western blot analysis of extracts of various cell lines, using PAFAH1B2 antibody (CAB12170) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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