Cell Biology Antibodies 9
Anti-PAEP Antibody (CAB5751)
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- SKU:
- CAB5751
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PAEP Antibody |
| Antibody SKU: | CAB5751 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-180 of human PAEP (NP_002562.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human |
| Positive Samples: | U-937, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-180 of human PAEP (NP_002562.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDIP QTKQ DLEL PKLA GTWH SMAM ATNN ISLM ATLK APLR VHIT SLLP TPED NLEI VLHR WENN SCVE KKVL GEKT ENPK KFKI NYTV ANEA TLLD TDYD NFLF LCLQ DTTT PIQS MMCQ YLAR VLVE DDEI MQGF IRAF RPLP RHLW YLLD LKQM EEPC RF |
| Gene ID: | 5047 |
| Uniprot: | P09466 |
| Cellular Location: | Secreted |
| Calculated MW: | 9kDa/18kDa/20kDa |
| Observed MW: | 26kDa |
| Synonyms: | PAEP, GD, GdA, GdF, GdS, PAEG, PEP, PP14 |
| Background: | This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PAEP: This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. Belongs to the calycin superfamily. Lipocalin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 9q34.3 Molecular Function:protein binding Biological Process: apoptosis; multicellular organismal development; positive regulation of granulocyte macrophage colony-stimulating factor production |
| NCBI Summary: | This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P09466 |
| NCBI GenInfo Identifier: | 130701 |
| NCBI Gene ID: | 5047 |
| NCBI Accession: | P09466.2 |
| UniProt Secondary Accession: | P09466,Q5T6T1, Q9UG92, |
| UniProt Related Accession: | P09466 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Glycodelin |
| NCBI Synonym Full Names: | progestagen associated endometrial protein |
| NCBI Official Symbol: | PAEP |
| NCBI Official Synonym Symbols: | GD; GdA; GdF; GdS; PEP; PAEG; PP14 |
| NCBI Protein Information: | glycodelin |
| UniProt Protein Name: | Glycodelin |
| UniProt Synonym Protein Names: | Placental protein 14; PP14; Pregnancy-associated endometrial alpha-2 globulin; PAEG; PEG; Progestagen-associated endometrial protein; Progesterone-associated endometrial protein |
| Protein Family: | Glycodelin |
| UniProt Gene Name: | PAEP |
 | Western blot analysis of extracts of various cell lines, using PAEP antibody (CAB5751) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using PAEP antibody (CAB5751). Blue: DAPI for nuclear staining. |
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