Cell Biology Antibodies 2
Anti-PADI2 Antibody (CAB12236)
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- SKU:
- CAB12236
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PADI2 Antibody |
| Antibody SKU: | CAB12236 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PADI2 (NP_031391.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, HT-29, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PADI2 (NP_031391.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLRE RTVR LQYG SRVE AVYV LGTY LWTD VYSA APAG AQTF SLKH SEHV WVEV VRDG EAEE VATN GKQR WLLS PSTT LRVT MSQA STEA SSDK VTVN YYDE EGSI PIDQ AGLF LTAI EISL DVDA DRDG VVEK NNPK KASW TWGP EGQG AILL VNCD RETP WLPK EDCR DEKV YSKE DLKD MSQM ILRT KGPD RLPA GYEI |
| Gene ID: | 11240 |
| Uniprot: | Q9Y2J8 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 49kDa/75kDa |
| Observed MW: | 75kDa |
| Synonyms: | PADI2, PAD-H19, PAD2, PDI2 |
| Background: | This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. |
| UniProt Protein Function: | PADI2: Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.5.3.15 Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: cytoplasm; cytosol Molecular Function:estrogen receptor binding; protein-arginine deiminase activity Biological Process: chromatin-mediated maintenance of transcription; establishment and/or maintenance of chromatin architecture; estrogen receptor signaling pathway; peptidyl-citrulline biosynthetic process from peptidyl-arginine; substantia nigra development |
| NCBI Summary: | This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2J8 |
| NCBI GenInfo Identifier: | 7531171 |
| NCBI Gene ID: | 11240 |
| NCBI Accession: | Q9Y2J8.2 |
| UniProt Secondary Accession: | Q9Y2J8,Q96DA7, Q9UPN2, |
| UniProt Related Accession: | Q9Y2J8 |
| Molecular Weight: | 49,310 Da |
| NCBI Full Name: | Protein-arginine deiminase type-2 |
| NCBI Synonym Full Names: | peptidyl arginine deiminase 2 |
| NCBI Official Symbol: | PADI2 |
| NCBI Official Synonym Symbols: | PAD2; PDI2; PAD-H19 |
| NCBI Protein Information: | protein-arginine deiminase type-2 |
| UniProt Protein Name: | Protein-arginine deiminase type-2 |
| UniProt Synonym Protein Names: | PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II |
| Protein Family: | Protein-arginine deiminase |
| UniProt Gene Name: | PADI2 |
| UniProt Entry Name: | PADI2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PADI2 antibody (CAB12236) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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