Cell Biology Antibodies 8

Anti-P2RY11 Antibody (CAB3061)

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SKU:
CAB3061

Description

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Antibody Name:Anti-P2RY11 Antibody
Antibody SKU:CAB3061
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human P2RY11
Application:IHC
Recommended Dilution:IHC 1:50 - 1:100
Reactivity:Human, Rat
Positive Samples:
Immunogen:Recombinant protein of human P2RY11
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5032
Uniprot:Q96G91
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:40kDa
Observed MW:
Synonyms:P2RY11, P2Y11
Background:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
UniProt Protein Function:P2RY11: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:ATP-activated nucleotide receptor activity; purinergic nucleotide receptor activity, G-protein coupled; receptor activity; neurotransmitter receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; adenylate cyclase activation; calcium-mediated signaling; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); defense response; adenosine receptor signaling pathway

NCBI Summary:The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
UniProt Code:Q96G91
NCBI GenInfo Identifier:21263830
NCBI Gene ID:5032
NCBI Accession:Q96G91.2
UniProt Secondary Accession:Q96G91,O43190, Q9BYU4, Q9H170, B2R8X9,
UniProt Related Accession:Q96G91
Molecular Weight:374
NCBI Full Name:P2Y purinoceptor 11
NCBI Synonym Full Names:purinergic receptor P2Y, G-protein coupled, 11
NCBI Official Symbol:P2RY11  
NCBI Official Synonym Symbols:P2Y11  
NCBI Protein Information:P2Y purinoceptor 11; purinergic receptor P2Y11
UniProt Protein Name:P2Y purinoceptor 11
Protein Family:P2Y purinoceptor
UniProt Gene Name:P2RY11  
UniProt Entry Name:P2Y11_HUMAN
Anti-P2RY11 Antibody (CAB3061)Immunohistochemistry of paraffin-embedded human rectal cancer using P2RY11 antibody (CAB3061) at dilution of 1:200 (40x lens).
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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