Signal Transduction Antibodies 1

Anti-P2RX6 Antibody (CAB10131)

(No reviews yet) Write a Review
SKU:
CAB10131
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-P2RX6 Antibody
Antibody SKU:CAB10131
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human P2RX6 (NP_001153026.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Mouse
Positive Samples:Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human P2RX6 (NP_001153026.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:WGLL DYKT EKWA LLAK KGYQ ERDL EPQF SIIT KLKG VSVT QIKE LGNR LWDV ADFV KPPQ GENV FFLV TNFL VTPA QVQG RCPE HPSV PLAN CWVD EDCP EGEG GTHS HGVK TGQC VVFN GTHR TCEI WSWC PVES GVVP SRPL LAQA QNFT LFIK NTVT FSKF NFSK SNAL ETWD PTYF KHCR YEPQ FSPY CPVF RIGD LVAK AGGT FEDL ALLG GSVG IRVH WDCD LDTG DSGC WPHY SFQL QEKS YNFR TATH WWEQ P
Gene ID:9127
Uniprot:O15547
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:45kDa/48kDa
Observed MW:49kDa
Synonyms:P2RX6, P2RXL1, P2X6, P2XM
Background:The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.
UniProt Protein Function:P2X6: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Receptor, misc.; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cell soma; integral to plasma membrane; postsynaptic density; cytoplasm; dendritic spine; integral to nuclear inner membrane; cell junction

Molecular Function:identical protein binding; transmembrane receptor activity; channel activity; purinergic nucleotide receptor activity; ATP binding; ATP-gated cation channel activity

Biological Process: muscle contraction; transport; protein heterooligomerization; signal transduction; transmembrane transport; protein homooligomerization; cation transport

NCBI Summary:The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]
UniProt Code:O15547
NCBI GenInfo Identifier:311033409
NCBI Gene ID:9127
NCBI Accession:O15547.2
UniProt Related Accession:O15547
Molecular Weight:45kDa; 48kDa
NCBI Full Name:P2X purinoceptor 6
NCBI Synonym Full Names:purinergic receptor P2X 6
NCBI Official Symbol:P2RX6  
NCBI Official Synonym Symbols:P2X6; P2XM; P2RXL1  
NCBI Protein Information:P2X purinoceptor 6
UniProt Protein Name:P2X purinoceptor 6
UniProt Synonym Protein Names:ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1
Protein Family:P2X purinoceptor
UniProt Gene Name:P2RX6  
UniProt Entry Name:P2RX6_HUMAN
Anti-P2RX6 Antibody (CAB10131)Western blot analysis of extracts of mouse pancreas, using P2RX6 antibody (CAB10131) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
View AllClose

0 Reviews

View AllClose

Related Products