Signal Transduction Antibodies 1
Anti-P2RX5 Antibody (CAB11710)
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- SKU:
- CAB11710
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-P2RX5 Antibody |
| Antibody SKU: | CAB11710 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 341-422 of human P2RX5 (NP_002552.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | NCI-H460, U-87MG, BxPC-3, K-562, Raji, Mouse heart, Mouse kidney, Mouse skeletal muscle, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 341-422 of human P2RX5 (NP_002552.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KKRE FYRD KKYE EVRG LEDS SQEA EDEA SGLG LSEQ LTSG PGLL GMPE QQEL QEPP EAKR GSSS QKGN GSVC PQLL EPHR ST |
| Gene ID: | 5026 |
| Uniprot: | Q93086 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa/47kDa/48kDa |
| Observed MW: | 115kDa |
| Synonyms: | P2RX5, LRH-1, P2X5, P2X5R |
| Background: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). |
| UniProt Protein Function: | P2X5: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; integral to nuclear inner membrane; plasma membrane Molecular Function:ATP-gated cation channel activity; ion channel activity; purinergic nucleotide receptor activity; transmembrane receptor activity Biological Process: blood coagulation; nervous system development; signal transduction; transport |
| NCBI Summary: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q93086 |
| NCBI GenInfo Identifier: | 209572778 |
| NCBI Gene ID: | 5026 |
| NCBI Accession: | Q93086.4 |
| UniProt Secondary Accession: | Q93086,O43450, O75540, Q308M5, Q59F38, Q8IXW4, Q93087 Q9NZV0, G5E981, |
| UniProt Related Accession: | Q93086 |
| Molecular Weight: | 44,531 Da |
| NCBI Full Name: | P2X purinoceptor 5 |
| NCBI Synonym Full Names: | purinergic receptor P2X 5 |
| NCBI Official Symbol: | P2RX5 |
| NCBI Official Synonym Symbols: | P2X5; LRH-1; P2X5R |
| NCBI Protein Information: | P2X purinoceptor 5 |
| UniProt Protein Name: | P2X purinoceptor 5 |
| UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
| Protein Family: | P2X purinoceptor |
| UniProt Gene Name: | P2RX5 |
| UniProt Entry Name: | P2RX5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using P2RX5 antibody (CAB11710) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of Jurkat cells using P2RX5 Rabbit pAb (CAB11710) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse spleen using P2RX5 Rabbit pAb (CAB11710) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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