Signal Transduction Antibodies 1
Anti-P2RX3 Antibody (CAB10232)
- SKU:
- CAB10232
Description
| Antibody Name: | Anti-P2RX3 Antibody |
| Antibody SKU: | CAB10232 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-317 of human P2RX3 (NP_002550.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-317 of human P2RX3 (NP_002550.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LHEK AYQV RDTA IESS VVTK VKGS GLYA NRVM DVSD YVTP PQGT SVFV IITK MIVT ENQM QGFC PESE EKYR CVSD SQCG PERL PGGG ILTG RCVN YSSV LRTC EIQG WCPT EVDT VETP IMME AENF TIFI KNSI RFPL FNFE KGNL LPNL TARD MKTC RFHP DKDP FCPI LRVG DVVK FAGQ DFAK LART GGVL GIKI GWVC DLDK AWDQ CIPK YSFT RLDS VSEK SSVS PGYN FRFA KYYK MENG SEYR TLLK AFGI RFDV LVYG NAGK FN |
| Gene ID: | 5024 |
| Uniprot: | P56373 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa |
| Observed MW: | 44kDa |
| Synonyms: | P2RX3, P2X3 |
| Background: | The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. |
| UniProt Protein Function: | P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12 Cellular Component: Golgi apparatus; cell soma; rough endoplasmic reticulum; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft Molecular Function:ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to ATP; response to carbohydrate stimulus; behavioral response to pain; transport; response to heat; response to mechanical stimulus; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization |
| NCBI Summary: | This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017] |
| UniProt Code: | P56373 |
| NCBI GenInfo Identifier: | 259016295 |
| NCBI Gene ID: | 5024 |
| NCBI Accession: | |
| UniProt Related Accession: | P56373 |
| Molecular Weight: | |
| NCBI Full Name: | P2X purinoceptor 3 |
| NCBI Synonym Full Names: | purinergic receptor P2X 3 |
| NCBI Official Symbol: | P2RX3 |
| NCBI Official Synonym Symbols: | P2X3 |
| NCBI Protein Information: | P2X purinoceptor 3 |
| UniProt Protein Name: | P2X purinoceptor 3 |
| UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
| UniProt Gene Name: | P2RX3 |
| UniProt Entry Name: | P2RX3_HUMAN |
 | Western blot analysis of extracts of rat testis, using P2RX3 antibody (CAB10232) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Signal Transduction |
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