Cell Death Antibodies 2

Anti-P2RX1 Antibody (CAB7914)

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SKU:
CAB7914
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-P2RX1 Antibody
Antibody SKU:CAB7914
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-330 of human P2RX1 (NP_002549.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 51-330 of human P2RX1 (NP_002549.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YEKG YQTS SGLI SSVS VKLK GLAV TQLP GLGP QVWD VADY VFPA QGDN SFVV MTNF IVTP KQTQ GYCA EHPE GGIC KEDS GCTP GKAK RKAQ GIRT GKCV AFND TVKT CEIF GWCP VEVD DDIP RPAL LREA ENFT LFIK NSIS FPRF KVNR RNLV EEVN AAHM KTCL FHKT LHPL CPVF QLGY VVQE SGQN FSTL AEKG GVVG ITID WHCD LDWH VRHC RPIY EFHG LYEE KNLS PGFN FRFA RHFV ENGT NYRH LFKV FGIR FDIL VDGK AGKF DIIP
Gene ID:5023
Uniprot:P51575
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:44kDa
Observed MW:Refer to figures
Synonyms:P2RX1, P2X1
Background:The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis.
UniProt Protein Function:P2X1: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family.
UniProt Protein Details:

Protein type:Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to nuclear inner membrane; plasma membrane; secretory granule membrane

Molecular Function:ATP-gated cation channel activity; cation channel activity; purinergic nucleotide receptor activity

Biological Process: blood coagulation; ion transport; neutrophil degranulation; signal transduction; transport

Disease: Bleeding Disorder, Platelet-type, 8

NCBI Summary:The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
UniProt Code:P51575
NCBI GenInfo Identifier:1709519
NCBI Gene ID:5023
NCBI Accession:P51575.1
UniProt Secondary Accession:P51575,Q9UK84,
UniProt Related Accession:P51575
Molecular Weight:45kDa
NCBI Full Name:P2X purinoceptor 1
NCBI Synonym Full Names:purinergic receptor P2X 1
NCBI Official Symbol:P2RX1  
NCBI Official Synonym Symbols:P2X1  
NCBI Protein Information:P2X purinoceptor 1
UniProt Protein Name:P2X purinoceptor 1
UniProt Synonym Protein Names:ATP receptor; Purinergic receptor
Protein Family:P2X purinoceptor
UniProt Gene Name:P2RX1  
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