Cell Death Antibodies 2
Anti-P2RX1 Antibody (CAB7914)
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- SKU:
- CAB7914
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-P2RX1 Antibody |
| Antibody SKU: | CAB7914 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 51-330 of human P2RX1 (NP_002549.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 51-330 of human P2RX1 (NP_002549.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YEKG YQTS SGLI SSVS VKLK GLAV TQLP GLGP QVWD VADY VFPA QGDN SFVV MTNF IVTP KQTQ GYCA EHPE GGIC KEDS GCTP GKAK RKAQ GIRT GKCV AFND TVKT CEIF GWCP VEVD DDIP RPAL LREA ENFT LFIK NSIS FPRF KVNR RNLV EEVN AAHM KTCL FHKT LHPL CPVF QLGY VVQE SGQN FSTL AEKG GVVG ITID WHCD LDWH VRHC RPIY EFHG LYEE KNLS PGFN FRFA RHFV ENGT NYRH LFKV FGIR FDIL VDGK AGKF DIIP |
| Gene ID: | 5023 |
| Uniprot: | P51575 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa |
| Observed MW: | Refer to figures |
| Synonyms: | P2RX1, P2X1 |
| Background: | The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. |
| UniProt Protein Function: | P2X1: Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family. |
| UniProt Protein Details: | Protein type:Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: integral to nuclear inner membrane; plasma membrane; secretory granule membrane Molecular Function:ATP-gated cation channel activity; cation channel activity; purinergic nucleotide receptor activity Biological Process: blood coagulation; ion transport; neutrophil degranulation; signal transduction; transport Disease: Bleeding Disorder, Platelet-type, 8 |
| NCBI Summary: | The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013] |
| UniProt Code: | P51575 |
| NCBI GenInfo Identifier: | 1709519 |
| NCBI Gene ID: | 5023 |
| NCBI Accession: | P51575.1 |
| UniProt Secondary Accession: | P51575,Q9UK84, |
| UniProt Related Accession: | P51575 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | P2X purinoceptor 1 |
| NCBI Synonym Full Names: | purinergic receptor P2X 1 |
| NCBI Official Symbol: | P2RX1 |
| NCBI Official Synonym Symbols: | P2X1 |
| NCBI Protein Information: | P2X purinoceptor 1 |
| UniProt Protein Name: | P2X purinoceptor 1 |
| UniProt Synonym Protein Names: | ATP receptor; Purinergic receptor |
| Protein Family: | P2X purinoceptor |
| UniProt Gene Name: | P2RX1 |
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