Anti-P23/PTGES3 Antibody (CAB5194)
- SKU:
- CAB5194
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- P23
- Synonyms:
- TEBP
- Synonyms:
- cPGES
- Research Area:
- Metabolism
Description
| Product Name: | P23/PTGES3 Rabbit mAb |
| Product Code: | CAB5194 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | P23, TEBP, cPGES |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human P23/PTGES3 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat testis, Rat brain, HeLa, HepG2, Jurkat, Mouse testis, Mouse brain |
| Immunogen: | A synthesized peptide derived from human P23/PTGES3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10728 |
| Uniprot: | Q15185 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
| UniProt Protein Function: | TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family. |
| UniProt Protein Details: | Protein type:Transferase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3; Isomerase Chromosomal Location of Human Ortholog: 12q13.3|12 Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; nucleoplasm; nucleus; telomerase holoenzyme complex Molecular Function:prostaglandin-E synthase activity; protein binding; telomerase activity; unfolded protein binding Biological Process: arachidonic acid metabolic process; cyclooxygenase pathway; prostaglandin biosynthetic process; RNA-dependent DNA replication; signal transduction; telomere maintenance |
| NCBI Summary: | This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q15185 |
| NCBI GenInfo Identifier: | 8928247 |
| NCBI Gene ID: | 10728 |
| NCBI Accession: | Q15185.1 |
| UniProt Secondary Accession: | Q15185,Q8WU70, A8K7D0, B4DHP2, B4DP11, B4DP21, |
| UniProt Related Accession: | Q15185 |
| Molecular Weight: | 16,476 Da |
| NCBI Full Name: | Prostaglandin E synthase 3 |
| NCBI Synonym Full Names: | prostaglandin E synthase 3 |
| NCBI Official Symbol: | PTGES3 |
| NCBI Official Synonym Symbols: | P23; TEBP; cPGES |
| NCBI Protein Information: | prostaglandin E synthase 3 |
| UniProt Protein Name: | Prostaglandin E synthase 3 |
| UniProt Synonym Protein Names: | Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 |
| UniProt Gene Name: | PTGES3 |
| UniProt Entry Name: | TEBP_HUMAN |
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