Neuroscience

Anti-OXT Antibody (CAB15296)

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SKU:
CAB15296
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Neuroscience

Description

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Antibody Name:Anti-OXT Antibody
Antibody SKU:CAB15296
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human OXT (NP_000906.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A549, NCI-H460, LO2, HepG2, Mouse liver, Rat liver, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human OXT (NP_000906.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGP SLAC CLLG LLAL TSAC YIQN CPLG GKRA APDL DVRK CLPC GPGG KGRC FGPN ICCA EELG CFVG TAEA LRCQ EENY LPSP CQSG QKAC GSGG RCAV LGLC CSPD GCHA DPAC DAEA TFSQ R
Gene ID:5020
Uniprot:P01178
Cellular Location:Secreted
Calculated MW:12kDa
Observed MW:13kDa
Synonyms:OXT, OT, OT-NPI, OXT-NPI
Background:This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
UniProt Protein Function:OXT: Neurophysin 1 specifically binds oxytocin. Belongs to the vasopressin/oxytocin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: extracellular region

Biological Process: signal transduction

NCBI Summary:This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]
UniProt Code:P01178
NCBI GenInfo Identifier:128071
NCBI Gene ID:5020
NCBI Accession:P01178.1
UniProt Secondary Accession:P01178,Q3MIG0,
UniProt Related Accession:P01178
Molecular Weight:12,722 Da
NCBI Full Name:Oxytocin-neurophysin 1
NCBI Synonym Full Names:oxytocin/neurophysin I prepropeptide
NCBI Official Symbol:OXT  
NCBI Official Synonym Symbols:OT; OT-NPI; OXT-NPI  
NCBI Protein Information:oxytocin-neurophysin 1
UniProt Protein Name:Oxytocin-neurophysin 1
UniProt Synonym Protein Names:OxytocinAlternative name(s):Ocytocin
Protein Family:Xylosyltransferase
UniProt Gene Name:OXT  
UniProt Entry Name:NEU1_HUMAN
Anti-OXT Antibody (CAB15296)Western blot analysis of extracts of various cell lines, using OXT antibody (CAB15296) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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