Immunology Antibodies 2
Anti-OX40 Antibody (CAB7499)
- SKU:
- CAB7499
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-OX40 Antibody |
| Antibody SKU: | CAB7499 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-214 of human OX40 (NP_003318.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, BT-474, SW620, MCF7, Mouse thymus, Mouse skeletal muscle, Mouse lung, Mouse intestine, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-214 of human OX40 (NP_003318.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LHCV GDTY PSND RCCH ECRP GNGM VSRC SRSQ NTVC RPCG PGFY NDVV SSKP CKPC TWCN LRSG SERK QLCT ATQD TVCR CRAG TQPL DSYK PGVD CAPC PPGH FSPG DNQA CKPW TNCT LAGK HTLQ PASN SSDA ICED RDPP ATQP QETQ GPPA RPIT VQPT EAWP RTSQ GPST RPVE VPGG RA |
| Gene ID: | 7293 |
| Uniprot: | P43489 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 37kDa |
| Synonyms: | TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
| UniProt Protein Function: | TNFRSF4: Receptor for TNFSF4/OX40L/GP34. |
| UniProt Protein Details: | Protein type:Apoptosis; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane Molecular Function:tumor necrosis factor receptor activity Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity Disease: Immunodeficiency 16 |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43489 |
| NCBI GenInfo Identifier: | 1171933 |
| NCBI Gene ID: | 7293 |
| NCBI Accession: | P43489.1 |
| UniProt Related Accession: | P43489 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 4 |
| NCBI Synonym Full Names: | TNF receptor superfamily member 4 |
| NCBI Official Symbol: | TNFRSF4 |
| NCBI Official Synonym Symbols: | OX40; ACT35; CD134; IMD16; TXGP1L |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 4 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 4 |
| UniProt Synonym Protein Names: | ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134 |
| UniProt Gene Name: | TNFRSF4 |
| UniProt Entry Name: | TNR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OX40 antibody (CAB7499) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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