Immunology Antibodies 2
Anti-OX40 Antibody (CAB3646)
- SKU:
- CAB3646
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-OX40 Antibody |
| Antibody SKU: | CAB3646 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human OX40 (NP_003318.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TATQ DTVC RCRA GTQP LDSY KPGV DCAP CPPG HFSP GDNQ ACKP WTNC TLAG KHTL QPAS NSSD AICE DRDP PATQ PQET QGPP ARPI TVQP TEAW PRTS Q |
| Gene ID: | 7293 |
| Uniprot: | P43489 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 29kDa |
| Observed MW: | 48kDa |
| Synonyms: | TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L |
| Background: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
| UniProt Protein Function: | TNFRSF4: Receptor for TNFSF4/OX40L/GP34. |
| UniProt Protein Details: | Protein type:Apoptosis; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane Molecular Function:tumor necrosis factor receptor activity Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity Disease: Immunodeficiency 16 |
| NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43489 |
| NCBI GenInfo Identifier: | 1171933 |
| NCBI Gene ID: | 7293 |
| NCBI Accession: | P43489.1 |
| UniProt Related Accession: | P43489 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 4 |
| NCBI Synonym Full Names: | TNF receptor superfamily member 4 |
| NCBI Official Symbol: | TNFRSF4 |
| NCBI Official Synonym Symbols: | OX40; ACT35; CD134; IMD16; TXGP1L |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 4 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 4 |
| UniProt Synonym Protein Names: | ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134 |
| UniProt Gene Name: | TNFRSF4 |
| UniProt Entry Name: | TNR4_HUMAN |
 | Western blot analysis of extracts of rat liver, using OX40 antibody (CAB3646) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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