Cell Biology Antibodies 17

Anti-Otx2 Antibody (CAB4351)

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SKU:
CAB4351
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Otx2 Antibody
Antibody SKU:CAB4351
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Otx2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, Y79, Mouse eye, Rat eye
Immunogen:A synthesized peptide derived from human Otx2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5015
Uniprot:P32243
Cellular Location:
Calculated MW:32kDa
Observed MW:35KDa
Synonyms:CPHD6, MCOPS5
Background:This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]
UniProt Protein Function:OTX2: Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. Expressed in brain. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q22.3

Cellular Component: growth cone; nucleus; protein complex

Molecular Function:eukaryotic initiation factor 4E binding; protein binding

Biological Process: axon guidance; forebrain development; midbrain development; positive regulation of embryonic development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of fibroblast growth factor receptor signaling pathway; regulation of smoothened signaling pathway

Disease: Microphthalmia, Syndromic 5; Pituitary Hormone Deficiency, Combined, 6

NCBI Summary:This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]
UniProt Code:P32243
NCBI GenInfo Identifier:417427
NCBI Gene ID:5015
NCBI Accession:P32243.1
UniProt Secondary Accession:P32243,Q6GTV3, Q9HAW3, Q9P2R1, B2RAN5,
UniProt Related Accession:P32243
Molecular Weight:32,406 Da
NCBI Full Name:Homeobox protein OTX2
NCBI Synonym Full Names:orthodenticle homeobox 2
NCBI Official Symbol:OTX2  
NCBI Official Synonym Symbols:CPHD6; MCOPS5  
NCBI Protein Information:homeobox protein OTX2
UniProt Protein Name:Homeobox protein OTX2
UniProt Synonym Protein Names:Orthodenticle homolog 2
Protein Family:Homeobox protein
UniProt Gene Name:OTX2  
Anti-Otx2 Antibody (CAB4351)Western blot - Otx2 Rabbit mAb (CAB4351)
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