| UniProt Protein Function: | OTUD5: a protein of unknown function. Contains a OTU-like cysteine protease domain. Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12 Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: cytosol Molecular Function: ubiquitin-specific protease activity Biological Process: innate immune response; response to lipopolysaccharide; proteolysis; negative regulation of interferon type I production |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q96G74 |
| NCBI GenInfo Identifier: | 209977019 |
| NCBI Gene ID: | 55593 |
| NCBI Accession: | NP_001129629.1 |
| UniProt Secondary Accession: | Q96G74,Q4KMN9, Q8N6T5, Q9H650, Q9H9U0, Q9NT65, B4DGG7 G5E9D7 |
| UniProt Related Accession: | Q96G74 |
| Molecular Weight: | |
| NCBI Full Name: | OTU domain-containing protein 5 isoform b |
| NCBI Synonym Full Names: | OTU deubiquitinase 5 |
| NCBI Official Symbol: | OTUD5 |
| NCBI Official Synonym Symbols: | DUBA |
| NCBI Protein Information: | OTU domain-containing protein 5; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A |
| UniProt Protein Name: | OTU domain-containing protein 5 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme A; DUBA |
| Protein Family: | |
| UniProt Gene Name: | OTUD5 |
| UniProt Entry Name: | OTUD5_HUMAN |
