Signal Transduction Antibodies 2
Anti-OTUB2 Antibody (CAB16251)
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- SKU:
- CAB16251
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-OTUB2 Antibody |
| Antibody SKU: | CAB16251 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human OTUB2 (NP_075601.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A549, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human OTUB2 (NP_075601.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSET SFNL ISEK CDIL SILR DHPE NRIY RRKI EELS KRFT AIRK TKGD GNCF YRAL GYSY LESL LGKS REIF K |
| Gene ID: | 78990 |
| Uniprot: | Q96DC9 |
| Cellular Location: | |
| Calculated MW: | 8kDa/27kDa |
| Observed MW: | 27kDa |
| Synonyms: | OTUB2, C14orf137, OTB2, OTU2 |
| Background: | This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. |
| UniProt Protein Function: | OTUB2: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C65 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Ubiquitin-specific protease; Hydrolase Chromosomal Location of Human Ortholog: 14q32.12 Cellular Component: nucleus Molecular Function:NEDD8-specific protease activity; protein binding; ubiquitin binding; ubiquitin-specific protease activity Biological Process: protein deubiquitination |
| NCBI Summary: | This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q96DC9 |
| NCBI GenInfo Identifier: | 44888285 |
| NCBI Gene ID: | 78990 |
| NCBI Accession: | Q96DC9.2 |
| UniProt Secondary Accession: | Q96DC9,Q6IA10, Q9H6T1, |
| UniProt Related Accession: | Q96DC9 |
| Molecular Weight: | 8,637 Da |
| NCBI Full Name: | Ubiquitin thioesterase OTUB2 |
| NCBI Synonym Full Names: | OTU deubiquitinase, ubiquitin aldehyde binding 2 |
| NCBI Official Symbol: | OTUB2 |
| NCBI Official Synonym Symbols: | OTB2; OTU2; C14orf137 |
| NCBI Protein Information: | ubiquitin thioesterase OTUB2 |
| UniProt Protein Name: | Ubiquitin thioesterase OTUB2 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme OTUB2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain-2; Ubiquitin-specific-processing protease OTUB2 |
| Protein Family: | Ubiquitin thioesterase |
| UniProt Gene Name: | OTUB2 |
| UniProt Entry Name: | OTUB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OTUB2 antibody (CAB16251) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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