Cell Biology Antibodies 14

Anti-OSBPL5 Antibody (CAB18148)

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SKU:
CAB18148
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-OSBPL5 Antibody
Antibody SKU:CAB18148
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human OSBPL5.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, LO2
Immunogen:Recombinant protein of human OSBPL5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:114879
Uniprot:Q9H0X9
Cellular Location:
Calculated MW:100kDa
Observed MW:115kDa
Anti-OSBPL5 Antibody (CAB18148)Western blot - OSBPL5 Polyclonal Antibody (CAB18148)
Synonyms:ORP5, OBPH1, OSBPL5
Background:This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified.
UniProt Protein Function:Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).
NCBI Summary:This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
UniProt Code:Q9H0X9
NCBI GenInfo Identifier:221136766
NCBI Gene ID:114879
NCBI Accession:NP_001137535.1
UniProt Secondary Accession:Q9H0X9,Q54A90, Q8N596, Q9BZB0, Q9P1Z4, A6NDP0, A6NJS8 B4DVB0,
UniProt Related Accession:Q9H0X9
Molecular Weight:88,435 Da
NCBI Full Name:oxysterol-binding protein-related protein 5 isoform b
NCBI Synonym Full Names:oxysterol binding protein like 5
NCBI Official Symbol:OSBPL5  
NCBI Official Synonym Symbols:ORP5; OBPH1  
NCBI Protein Information:oxysterol-binding protein-related protein 5
UniProt Protein Name:Oxysterol-binding protein-related protein 5
UniProt Synonym Protein Names:Oxysterol-binding protein homolog 1
Protein Family:Oxysterol-binding protein-related protein
UniProt Gene Name:OSBPL5  
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