Cell Biology Antibodies 14
Anti-OSBPL5 Antibody (CAB18148)
- SKU:
- CAB18148
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-OSBPL5 Antibody |
Antibody SKU: | CAB18148 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human OSBPL5. |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | HeLa, LO2 |
Immunogen: | Recombinant protein of human OSBPL5. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 114879 |
Uniprot: | Q9H0X9 |
Cellular Location: | |
Calculated MW: | 100kDa |
Observed MW: | 115kDa |
Synonyms: | ORP5, OBPH1, OSBPL5 |
Background: | This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. |
UniProt Protein Function: | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). |
NCBI Summary: | This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] |
UniProt Code: | Q9H0X9 |
NCBI GenInfo Identifier: | 221136766 |
NCBI Gene ID: | 114879 |
NCBI Accession: | NP_001137535.1 |
UniProt Secondary Accession: | Q9H0X9,Q54A90, Q8N596, Q9BZB0, Q9P1Z4, A6NDP0, A6NJS8 B4DVB0, |
UniProt Related Accession: | Q9H0X9 |
Molecular Weight: | 88,435 Da |
NCBI Full Name: | oxysterol-binding protein-related protein 5 isoform b |
NCBI Synonym Full Names: | oxysterol binding protein like 5 |
NCBI Official Symbol: | OSBPL5 |
NCBI Official Synonym Symbols: | ORP5; OBPH1 |
NCBI Protein Information: | oxysterol-binding protein-related protein 5 |
UniProt Protein Name: | Oxysterol-binding protein-related protein 5 |
UniProt Synonym Protein Names: | Oxysterol-binding protein homolog 1 |
Protein Family: | Oxysterol-binding protein-related protein |
UniProt Gene Name: | OSBPL5 |