Cell Biology Antibodies 5
Anti-ORMDL3 Antibody (CAB14951)
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- SKU:
- CAB14951
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ORMDL3 Antibody |
| Antibody SKU: | CAB14951 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ORMDL3 (NP_644809.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse eye, Mouse thymus, Mouse liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ORMDL3 (NP_644809.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNVG TAHS EVNP NTRV MNSR GIWL SYVL AIGL LHIV LLSI PFVS VPVV WTLT NLIH NMGM YIFL HTVK GTPF ETPD QGKA RLLT HWEQ MDYG VQFT ASRK |
| Gene ID: | 94103 |
| Uniprot: | Q8N138 |
| Cellular Location: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| Calculated MW: | 15kDa/17kDa |
| Observed MW: | 17kDa |
| Synonyms: | ORMDL3 |
| Background: |
| UniProt Protein Function: | ORMDL3: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Belongs to the ORM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q12 Cellular Component: endoplasmic reticulum Molecular Function:protein binding Biological Process: ceramide metabolic process |
| UniProt Code: | Q8N138 |
| NCBI GenInfo Identifier: | 74728486 |
| NCBI Gene ID: | 94103 |
| NCBI Accession: | Q8N138.1 |
| UniProt Secondary Accession: | Q8N138,Q6UY83, B3KS83, |
| UniProt Related Accession: | Q8N138 |
| Molecular Weight: | 15,689 Da |
| NCBI Full Name: | ORM1-like protein 3 |
| NCBI Synonym Full Names: | ORMDL sphingolipid biosynthesis regulator 3 |
| NCBI Official Symbol: | ORMDL3 |
| NCBI Protein Information: | ORM1-like protein 3 |
| UniProt Protein Name: | ORM1-like protein 3 |
| Protein Family: | ORM1-like protein |
| UniProt Gene Name: | ORMDL3 |
| UniProt Entry Name: | ORML3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ORMDL3 antibody (CAB14951) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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