Cell Biology Antibodies 12
Anti-Orexin Antibody (CAB9821)
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- SKU:
- CAB9821
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Orexin Antibody |
| Antibody SKU: | CAB9821 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-131 of human HCRT (NP_001515.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-131 of human HCRT (NP_001515.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPLP DCCR QKTC SCRL YELL HGAG NHAA GILT LGKR RSGP PGLQ GRLQ RLLQ ASGN HAAG ILTM GRRA GAEP APRP CLGR RCSA PAAA SVAP GGQS GI |
| Gene ID: | 3060 |
| Uniprot: | O43612 |
| Cellular Location: | Cell junction, Cytoplasmic vesicle, Rough endoplasmic reticulum, synapse |
| Calculated MW: | 13kDa |
| Observed MW: | 16kDa |
| Synonyms: | HCRT, NRCLP1, OX, PPOX, orexin |
| Background: | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. |
| UniProt Protein Function: | HCRT: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1). Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Belongs to the orexin family. |
| UniProt Protein Details: | Protein type:Hormone Chromosomal Location of Human Ortholog: 17q21 Cellular Component: synaptic vesicle; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region; cell junction; secretory granule Molecular Function:type 2 hypocretin receptor binding; type 1 hypocretin receptor binding Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; neuropeptide signaling pathway; eating behavior; negative regulation of DNA replication; negative regulation of potassium ion transport; protein kinase C activation; regulation of neurotransmitter secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; positive regulation of transmission of nerve impulse Disease: Narcolepsy 1 |
| NCBI Summary: | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] |
| UniProt Code: | O43612 |
| NCBI GenInfo Identifier: | 4557635 |
| NCBI Gene ID: | 3060 |
| NCBI Accession: | NP_001515.1 |
| UniProt Related Accession: | O43612 |
| Molecular Weight: | 13,363 Da |
| NCBI Full Name: | orexin |
| NCBI Synonym Full Names: | hypocretin (orexin) neuropeptide precursor |
| NCBI Official Symbol: | HCRT |
| NCBI Official Synonym Symbols: | OX; PPOX; NRCLP1 |
| NCBI Protein Information: | orexin |
| UniProt Protein Name: | Orexin |
| UniProt Synonym Protein Names: | Hypocretin; Hcrt |
| UniProt Gene Name: | HCRT |
| UniProt Entry Name: | OREX_HUMAN |
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