Cell Biology Antibodies 18

Anti-ORC5 Antibody (CAB18343)

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SKU:
CAB18343
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ORC5 Antibody
Antibody SKU:CAB18343
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ORC5.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:
Immunogen:Recombinant protein of human ORC5.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5001
Uniprot:O43913
Cellular Location:
Calculated MW:50kDa
Observed MW:Refer to figures
Synonyms:ORC5, ORC5L, ORC5P, ORC5T, PPP1R117
Background:The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described.
UniProt Protein Function:ORC5L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC5 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: nucleoplasm; cytoplasm; nuclear origin of replication recognition complex; nucleus; origin recognition complex

Molecular Function:protein binding; nucleotide binding; DNA replication origin binding; ATP binding

Biological Process: DNA replication initiation; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle

NCBI Summary:The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
UniProt Code:O43913
NCBI GenInfo Identifier:6174924
NCBI Gene ID:5001
NCBI Accession:O43913.1
UniProt Secondary Accession:O43913,O60590, O95268, A4D0P8,
UniProt Related Accession:O43913
Molecular Weight:435
NCBI Full Name:Origin recognition complex subunit 5
NCBI Synonym Full Names:origin recognition complex, subunit 5
NCBI Official Symbol:ORC5  
NCBI Official Synonym Symbols:ORC5L; ORC5P; ORC5T; PPP1R117  
NCBI Protein Information:origin recognition complex subunit 5; protein phosphatase 1, regulatory subunit 117
UniProt Protein Name:Origin recognition complex subunit 5
Protein Family:Origin recognition complex
UniProt Gene Name:ORC5  
UniProt Entry Name:ORC5_HUMAN
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