Cell Biology Antibodies 7

Anti-OPTC Antibody (CAB16514)

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SKU:
CAB16514
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-OPTC Antibody
Antibody SKU:CAB16514
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-115 of human OPTC (NP_055174.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ASLP RKER KRRE EQMP REGD SFEV LPLR NDVL NPDN YGEV IDLS NYEE LTDY GDQL PEVK VTSL APAT SISP AKST TAPG TPSS NPTM TRPT TAGL
Gene ID:26254
Uniprot:Q9UBM4
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:37kDa
Observed MW:54kDa
Synonyms:OPTC, OPT, opticin
Background:Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).
UniProt Protein Function:OPTC: Binds collagen fibrils. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: proteinaceous extracellular matrix

Molecular Function:extracellular matrix structural constituent

Biological Process: negative regulation of angiogenesis

NCBI Summary:Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq]
UniProt Code:Q9UBM4
NCBI GenInfo Identifier:5777529
NCBI Gene ID:26254
NCBI Accession:
UniProt Secondary Accession:Q9UBM4,Q5T2G4,
UniProt Related Accession:Q9UBM4
Molecular Weight:37,261 Da
NCBI Full Name:opticin
NCBI Synonym Full Names:opticin
NCBI Official Symbol:OPTC  
NCBI Official Synonym Symbols:OPT; OPTC  
NCBI Protein Information:opticin; oculoglycan
UniProt Protein Name:Opticin
UniProt Synonym Protein Names:Oculoglycan
Protein Family:Opticin
UniProt Gene Name:OPTC  
UniProt Entry Name:OPT_HUMAN
Anti-OPTC Antibody (CAB16514)Western blot analysis of extracts of various cell lines, using OPTC antibody (CAB16514) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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