Epigenetics & Nuclear Signaling Antibodies 4
Anti-ONECUT1 Antibody (CAB9668)
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- SKU:
- CAB9668
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ONECUT1 Antibody |
| Antibody SKU: | CAB9668 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-292 of human ONECUT1 (NP_004489.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 167-292 of human ONECUT1 (NP_004489.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PYHK DVAG MGQS LSPL SSSG LGSI HNSQ QGLP HYAH PGAA MPTD KMLT PNGF EAHH PAML GRHG EQHL TPTS AGMV PING LPPH HPHA HLNA QGHG QLLG TARE PNPS VTGA QVSN GSNS GQME EI |
| Gene ID: | 3175 |
| Uniprot: | Q9UBC0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 51kDa |
| Observed MW: | 55kDa |
| Synonyms: | ONECUT1, HNF-6, HNF6, HNF6A |
| Background: | This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ONECUT1: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Belongs to the CUT homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 15q21.3 Cellular Component: nucleus Molecular Function:DNA binding Biological Process: spleen development; cell fate commitment; transcription, DNA-dependent; regulation of cell-matrix adhesion; system development; glucose metabolic process; liver development; endocrine pancreas development; regulation of transcription, DNA-dependent; B cell differentiation; epithelial cell development; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; endoderm development |
| NCBI Summary: | This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9UBC0 |
| NCBI GenInfo Identifier: | 13627184 |
| NCBI Gene ID: | 3175 |
| NCBI Accession: | Q9UBC0.1 |
| UniProt Related Accession: | Q9UBC0 |
| Molecular Weight: | |
| NCBI Full Name: | Hepatocyte nuclear factor 6 |
| NCBI Synonym Full Names: | one cut homeobox 1 |
| NCBI Official Symbol: | ONECUT1 |
| NCBI Official Synonym Symbols: | HNF6; HNF-6; HNF6A |
| NCBI Protein Information: | hepatocyte nuclear factor 6 |
| UniProt Protein Name: | Hepatocyte nuclear factor 6 |
| UniProt Synonym Protein Names: | One cut domain family member 1; One cut homeobox 1 |
| UniProt Gene Name: | ONECUT1 |
| UniProt Entry Name: | HNF6_HUMAN |
 | Western blot analysis of extracts of mouse spleen, using ONECUT1 antibody (CAB9668) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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