Cell Biology Antibodies 5
Anti-OMA1 Antibody (CAB14437)
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- SKU:
- CAB14437
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-OMA1 Antibody |
| Antibody SKU: | CAB14437 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, LO2, K-562, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AICP RDSL ALLC QWIQ SKLQ EYMF NRPY SRKL EAEA DKIG LLLA AKAC ADIR ASSV FWQQ MEFV DSLH GQPK MPEW LSTH PSHG NRVE YLDR LIPQ ALKI REMC NCPP LSNP DPRL LFKL STKH FLEE SEKE DLNI TKKQ KMDT LPIQ KQEQ IPLT YIVE KRTG S |
| Gene ID: | 115209 |
| Uniprot: | Q96E52 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 55kDa/60kDa |
| Observed MW: | 60kDa |
| Synonyms: | OMA1, 2010001O09Rik, DAB1, MPRP-1, MPRP1, YKR087C, ZMPOMA1, peptidase |
| Background: |
| UniProt Protein Function: | OMA1: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase M48 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Membrane protein, multi-pass; Membrane protein, integral; EC 3.4.24.- Chromosomal Location of Human Ortholog: 1p32.2-p32.1 Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrial membrane Molecular Function:metal ion binding; metalloendopeptidase activity Biological Process: cristae formation; diet induced thermogenesis; glucose metabolic process; lipid metabolic process; misfolded or incompletely synthesized protein catabolic process; response to stress |
| UniProt Code: | Q96E52 |
| NCBI GenInfo Identifier: | 21686999 |
| NCBI Gene ID: | 115209 |
| NCBI Accession: | NP_660286.1 |
| UniProt Secondary Accession: | Q96E52,Q5T3G6, Q5T3G7, Q5T3G8, Q5T3G9, Q5T3H0, Q8NBB3 D3DQ54, |
| UniProt Related Accession: | Q96E52 |
| Molecular Weight: | 55,744 Da |
| NCBI Full Name: | metalloendopeptidase OMA1, mitochondrial |
| NCBI Synonym Full Names: | OMA1 zinc metallopeptidase |
| NCBI Official Symbol: | OMA1 |
| NCBI Official Synonym Symbols: | DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik |
| NCBI Protein Information: | metalloendopeptidase OMA1, mitochondrial |
| UniProt Protein Name: | Metalloendopeptidase OMA1, mitochondrial |
| UniProt Synonym Protein Names: | Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog |
| Protein Family: | Metalloendopeptidase |
| UniProt Gene Name: | OMA1 |
| UniProt Entry Name: | OMA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OMA1 antibody (CAB14437) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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