Metabolism Antibodies 1
Anti-OGDHL Antibody (CAB15475)
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- SKU:
- CAB15475
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-OGDHL Antibody |
| Antibody SKU: | CAB15475 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OGDHL (NP_060715.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, Mouse kidney, Mouse brain, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OGDHL (NP_060715.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSQL RLLP SRLG VQAA RLLA AHDV PVFG WRSR SSGP PATF PSSK GGGG SSYM EEMY FAWL ENPQ SVHK SWDS FFRE ASEE AFSG SAQP RPPS VVHE SRSA VSSR TKTS KL |
| Gene ID: | 55753 |
| Uniprot: | Q9ULD0 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 91kDa/108kDa/114kDa |
| Observed MW: | 120kDa |
| Synonyms: | OGDHL |
| Background: | The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. |
| UniProt Protein Function: | OGDHL: Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Oxidoreductase; EC 1.2.4.-; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - citrate (TCA) cycle Chromosomal Location of Human Ortholog: 10q11.23 Cellular Component: mitochondrion; mitochondrial matrix; oxoglutarate dehydrogenase complex; cytosol Molecular Function:protein binding; metal ion binding; thiamin pyrophosphate binding; oxoglutarate dehydrogenase (succinyl-transferring) activity Biological Process: glycolysis; tricarboxylic acid cycle |
| NCBI Summary: | The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016] |
| UniProt Code: | Q9ULD0 |
| NCBI GenInfo Identifier: | 160419019 |
| NCBI Gene ID: | 55753 |
| NCBI Accession: | Q9ULD0.3 |
| UniProt Related Accession: | Q9ULD0 |
| Molecular Weight: | 91kDa; 108kDa; 114kDa |
| NCBI Full Name: | 2-oxoglutarate dehydrogenase-like, mitochondrial |
| NCBI Synonym Full Names: | oxoglutarate dehydrogenase like |
| NCBI Official Symbol: | OGDHL |
| NCBI Protein Information: | 2-oxoglutarate dehydrogenase-like, mitochondrial |
| UniProt Protein Name: | 2-oxoglutarate dehydrogenase-like, mitochondrial |
| UniProt Synonym Protein Names: | 2-oxoglutarate dehydrogenase complex component E1-like; OGDC-E1-like; Alpha-ketoglutarate dehydrogenase-like |
| Protein Family: | 2-oxoglutarate dehydrogenase |
| UniProt Gene Name: | OGDHL |
| UniProt Entry Name: | OGDHL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using OGDHL antibody (CAB15475) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human esophageal using OGDHL Rabbit pAb (CAB15475) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using OGDHL Rabbit pAb (CAB15475) at dilution of 1:200 (40x lens). |
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