Signal Transduction Antibodies 3

Anti-OCA2 Antibody (CAB5653)

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SKU:
CAB5653
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-OCA2 Antibody
Antibody SKU:CAB5653
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, U-937, Mouse eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MHLE GRDG RRYP GAPA VELL QTSV PSGL AELV AGKR RLPR GAGG ADPS HSCP RGAA GQSS WAPA GQEF ASFL TKGR SHSS LPQM SSSR SKDS CFTE NTPL LRNS LQEK GSRC IPVY HPEF ITAE ESWE DSSA DWER RYLL SREV SGLS ASAS SEKG DLLD SPHI RLRL SKLR RCVQ WLKV
Gene ID:4948
Uniprot:Q04671
Cellular Location:Melanosome membrane, Multi-pass membrane protein
Calculated MW:74kDa/90kDa/92kDa
Observed MW:65-80kDa
Synonyms:OCA2, BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1, P protein
Background:This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family.
UniProt Protein Details:

Protein type:Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q

Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; cytoplasm; melanosome membrane; integral to membrane; endosome membrane

Molecular Function:protein binding; transporter activity; L-tyrosine transmembrane transporter activity

Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; transmembrane transport; eye pigment biosynthetic process; spermatid development

Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1

NCBI Summary:This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:Q04671
NCBI GenInfo Identifier:90110050
NCBI Gene ID:4948
NCBI Accession:Q04671.2
UniProt Secondary Accession:Q04671,Q15211, Q15212, Q96EN1, Q9UMI5,
UniProt Related Accession:Q04671
Molecular Weight:838
NCBI Full Name:P protein
NCBI Synonym Full Names:oculocutaneous albinism II
NCBI Official Symbol:OCA2  
NCBI Official Synonym Symbols:P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12  
NCBI Protein Information:P protein; P-protein; eye color 3 (brown); hair color 3 (brown); eye color 2 (central brown); total brown iris pigmentation; pink-eyed dilution protein homolog; melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution homolog, mouse)
UniProt Protein Name:P protein
UniProt Synonym Protein Names:Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
Protein Family:P protein
UniProt Gene Name:OCA2  
UniProt Entry Name:P_HUMAN
Anti-OCA2 Antibody (CAB5653)Western blot analysis of extracts of various cell lines, using OCA2 antibody (CAB5653) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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