Cell Biology Antibodies 14
Anti-OBSCN Antibody (CAB18110)
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- SKU:
- CAB18110
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-OBSCN Antibody |
| Antibody SKU: | CAB18110 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human OBSCN. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human OBSCN. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84033 |
| Uniprot: | Q5VST9 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
 | Immunofluorescence - OBSCN Polyclonal Antibody (CAB18110) |
| Synonyms: | ARHGEF30, UNC89, OBSCN |
| Background: |
| UniProt Protein Function: | OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; CAMK group; Trio family Chromosomal Location of Human Ortholog: 1q42.13 Cellular Component: myofibril; M band; Z disc; cytosol Molecular Function:calmodulin binding; protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; metal ion binding; titin binding; ankyrin binding; ATP binding Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; small GTPase mediated signal transduction; sarcomere organization; protein amino acid phosphorylation |
| NCBI Summary: | The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5VST9 |
| NCBI GenInfo Identifier: | 15026974 |
| NCBI Gene ID: | 84033 |
| NCBI Accession: | CAC44768.1 |
| UniProt Secondary Accession: | Q5VST9,Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0 Q8NHN1, Q8NHN2, Q8NHN3, Q8NHN4, Q8NHN5, |
| UniProt Related Accession: | Q5VST9 |
| Molecular Weight: | 868,484 Da |
| NCBI Full Name: | obscurin |
| NCBI Synonym Full Names: | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF |
| NCBI Official Symbol: | OBSCN |
| NCBI Official Synonym Symbols: | UNC89; ARHGEF30 |
| NCBI Protein Information: | obscurin; obscurin-MLCK; obscurin, myosin light chain kinase |
| UniProt Protein Name: | Obscurin |
| UniProt Synonym Protein Names: | Obscurin-RhoGEF; Obscurin-myosin light chain kinase |
| Protein Family: | Obscurin |
| UniProt Gene Name: | OBSCN |
| UniProt Entry Name: | OBSCN_HUMAN |
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