Cell Biology Antibodies 14

Anti-OBSCN Antibody (CAB18110)

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SKU:
CAB18110
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-OBSCN Antibody
Antibody SKU:CAB18110
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human OBSCN.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human OBSCN.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84033
Uniprot:Q5VST9
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Anti-OBSCN Antibody (CAB18110)Immunofluorescence - OBSCN Polyclonal Antibody (CAB18110)
Synonyms:ARHGEF30, UNC89, OBSCN
Background:
UniProt Protein Function:OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; CAMK group; Trio family

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: myofibril; M band; Z disc; cytosol

Molecular Function:calmodulin binding; protein serine/threonine kinase activity; protein binding; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; metal ion binding; titin binding; ankyrin binding; ATP binding

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; small GTPase mediated signal transduction; sarcomere organization; protein amino acid phosphorylation

NCBI Summary:The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q5VST9
NCBI GenInfo Identifier:15026974
NCBI Gene ID:84033
NCBI Accession:CAC44768.1
UniProt Secondary Accession:Q5VST9,Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0 Q8NHN1, Q8NHN2, Q8NHN3, Q8NHN4, Q8NHN5,
UniProt Related Accession:Q5VST9
Molecular Weight:868,484 Da
NCBI Full Name:obscurin
NCBI Synonym Full Names:obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
NCBI Official Symbol:OBSCN  
NCBI Official Synonym Symbols:UNC89; ARHGEF30  
NCBI Protein Information:obscurin; obscurin-MLCK; obscurin, myosin light chain kinase
UniProt Protein Name:Obscurin
UniProt Synonym Protein Names:Obscurin-RhoGEF; Obscurin-myosin light chain kinase
Protein Family:Obscurin
UniProt Gene Name:OBSCN  
UniProt Entry Name:OBSCN_HUMAN
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