Cell Biology Antibodies 6
Anti-OBFC1 Antibody (CAB16146)
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- SKU:
- CAB16146
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-OBFC1 Antibody |
| Antibody SKU: | CAB16146 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human OBFC1 (NP_079204.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human OBFC1 (NP_079204.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MQPG SSRC EEET PSLL WGLD PVFL AFAK LYIR DILD MKES RQVP GVFL YNGH PIKQ VDVL GTVI GVRE RDAF YSYG VDDS TGVI NCIC WKKL NTES VSAA PSAA RELS LTSQ LKKL QETI EQKT KIEI GDTI RVRG SIRT YREE REIH ATTY YKVD DPVW NIQI ARML ELPT IYRK VYDQ PFHS SALE KEEA LSNP GALD LPSL TSLL SEKA KEFL MENR VQSF YQQE LEMV ESLL SLAN QPVI HSAS SDQV NFKK DTTS KAIH SIFK NAIQ LLQE KGLV FQKD DGFD NLYY VTRE DKDL HRKI HRII QQDC QKPN HMEK GCHF LHIL ACAR LSIR PGLS EAVL QQVL ELLE DQSD IVST MEHY YTAF |
| Gene ID: | 79991 |
| Uniprot: | Q9H668 |
| Cellular Location: | Chromosome, Nucleus, telomere |
| Calculated MW: | 42kDa |
| Observed MW: | 45kDa |
| Synonyms: | STN1, AAF-44, AAF44, OBFC1, RPA-32, bA541N10.2 |
| Background: | OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication. OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130). |
| UniProt Protein Function: | OBFC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Belongs to the STN1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: intermediate filament cytoskeleton; intracellular membrane-bound organelle; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; single-stranded DNA binding; single-stranded telomeric DNA binding; telomeric DNA binding Biological Process: negative regulation of telomerase activity; positive regulation of DNA replication; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; telomere maintenance |
| NCBI Summary: | OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009] |
| UniProt Code: | Q9H668 |
| NCBI GenInfo Identifier: | 62900737 |
| NCBI Gene ID: | 79991 |
| NCBI Accession: | Q9H668.2 |
| UniProt Secondary Accession: | Q9H668,Q5TCZ0, D3DR99, |
| UniProt Related Accession: | Q9H668 |
| Molecular Weight: | 42,119 Da |
| NCBI Full Name: | CST complex subunit STN1 |
| NCBI Synonym Full Names: | oligonucleotide/oligosaccharide binding fold containing 1 |
| NCBI Official Symbol: | OBFC1 |
| NCBI Official Synonym Symbols: | STN1; AAF44; AAF-44; RPA-32; bA541N10.2 |
| NCBI Protein Information: | CST complex subunit STN1 |
| UniProt Protein Name: | CST complex subunit STN1 |
| UniProt Synonym Protein Names: | Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog |
| Protein Family: | CST complex |
| UniProt Gene Name: | OBFC1 |
| UniProt Entry Name: | STN1_HUMAN |
 | Western blot analysis of extracts of 293T cells, using OBFC1 antibody (CAB16146) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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