Immunology Antibodies 1

Anti-OASL Antibody (CAB10527)

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SKU:
CAB10527
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-OASL Antibody
Antibody SKU:CAB10527
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 315-514 of human OASL (NP_003724.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:1000
Reactivity:Human
Positive Samples:MCF7, SH-SY5Y
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 315-514 of human OASL (NP_003724.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EGYR WDIV AQRA SQCL KQDC CYDN RENP ISSW NVKR ARDI HLTV EQRG YPDF NLIV NPYE PIRK VKEK IRRT RGYS GLQR LSFQ VPGS ERQL LSSR CSLA KYGI FSHT HIYL LETI PSEI QVFV KNPD GGSY AYAI NPNS FILG LKQQ IEDQ QGLP KKQQ QLEF QGQV LQDW LGLG IYGI QDSD TLIL SKKK GEAL FPAS
Gene ID:8638
Uniprot:Q15646
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:29kDa/43kDa/59kDa
Observed MW:75kDa
Synonyms:OASL, OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL
Background:
UniProt Protein Function:OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1.
UniProt Protein Details:

Protein type:DNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm

Molecular Function:2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; RNA binding; thyroid hormone receptor binding

Biological Process: negative regulation of viral genome replication; response to virus

UniProt Code:Q15646
NCBI GenInfo Identifier:6226835
NCBI Gene ID:8638
NCBI Accession:Q15646.2
UniProt Secondary Accession:Q15646,O75686, Q17R95, Q9Y6K6, Q9Y6K7, B2RAZ2, I1YDD2
UniProt Related Accession:Q15646
Molecular Weight:59kDa
NCBI Full Name:2'-5'-oligoadenylate synthase-like protein
NCBI Synonym Full Names:2'-5'-oligoadenylate synthetase like
NCBI Official Symbol:OASL  
NCBI Official Synonym Symbols:OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL  
NCBI Protein Information:2'-5'-oligoadenylate synthase-like protein
UniProt Protein Name:2'-5'-oligoadenylate synthase-like protein
UniProt Synonym Protein Names:2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL
Protein Family:2'-5'-oligoadenylate synthase-like protein
UniProt Gene Name:OASL  
Anti-OASL Antibody (CAB10527)Western blot analysis of extracts of various cell lines, using OASL antibody (CAB10527) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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