Signal Transduction Antibodies 3
Anti-NYX Antibody (CAB7830)
- SKU:
- CAB7830
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Antibody Name: | Anti-NYX Antibody |
Antibody SKU: | CAB7830 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-481 of human NYX (NP_072089.1). |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Reactivity: | Human, Mouse |
Positive Samples: | 293T |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-481 of human NYX (NP_072089.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LLYL DRNS IAFV EEGA FQNL SGLL ALHL NGNR LTVL AWVA FQPG FFLG RLFL FRNP WCCD CRLE WLRD WMEG SGRV TDVP CASP GSVA GLDL SQVT FGRS SDGL CVDP EELN LTTS SPGP SPEP AATT VSRF SSLL SKLL APRV PVEE AANT TGGL ANAS LSDS LSSR GVGG AGRQ PWFL LASC LLPS VAQH VVFG LQMD |
Gene ID: | 60506 |
Uniprot: | Q9GZU5 |
Cellular Location: | Secreted, extracellular matrix, extracellular space |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
Synonyms: | NYX, CLRP, CSNB1, CSNB1A, CSNB4, NBM1 |
Background: | The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. |
UniProt Protein Function: | NYX: Defects in NYX are the cause of congenital stationary night blindness type 1A (CSNB1A); also called X- linked congenital stationary night blindness (XLCSNB). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNB1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: cytoplasm; intracellular; proteinaceous extracellular matrix Molecular Function:protein kinase inhibitor activity Biological Process: cytokine-mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; visual perception Disease: Night Blindness, Congenital Stationary, Type 1a |
UniProt Code: | Q9GZU5 |
NCBI GenInfo Identifier: | 12007646 |
NCBI Gene ID: | |
NCBI Accession: | NP_072089.1 |
Molecular Weight: | 52kDa |
NCBI Full Name: | nyctalopin |
UniProt Protein Name: | Nyctalopin |
Protein Family: | Nyctalopin |
UniProt Gene Name: | NYX |
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