Cell Biology Antibodies 13
Anti-NXN Antibody (CAB17206)
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- SKU:
- CAB17206
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NXN Antibody |
| Antibody SKU: | CAB17206 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human NXN (NP_001192248.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CRSL TRVL VESY RKIK EAGQ NFEI IFVS ADRS EESF KQYF SEMP WLAV PYTD EARR SRLN RLYG IQGI PTLI MLDP QGEV ITRQ GRVE VLND EDCR EFPW HPKP VLEL SDSN AAQL NEGP CLVL FVDS EDDG ESEA AKQL IQPI AEKI IAKY KAKE EEAP LLFF VAGE DDMT DSLR DYTN L |
| Gene ID: | 64359 |
| Uniprot: | Q6DKJ4 |
| Cellular Location: | |
| Calculated MW: | 20kDa/36kDa/48kDa |
| Observed MW: | 48kDa |
 | Western blot - NXN Rabbit pAb (CAB17206) |
| Synonyms: | NXN, NRX, TRG-4 |
| Background: | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. |
| UniProt Protein Function: | NXN: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Belongs to the nucleoredoxin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.8.1.8; Oxidoreductase Chromosomal Location of Human Ortholog: 17p13.3 Biological Process: negative regulation of protein ubiquitination; negative regulation of Wnt receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q6DKJ4 |
| NCBI GenInfo Identifier: | 187471109 |
| NCBI Gene ID: | 64359 |
| NCBI Accession: | Q6DKJ4.2 |
| UniProt Secondary Accession: | Q6DKJ4,Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1, B4DXQ0, D3DTH2 |
| UniProt Related Accession: | Q6DKJ4 |
| Molecular Weight: | 36,871 Da |
| NCBI Full Name: | Nucleoredoxin |
| NCBI Synonym Full Names: | nucleoredoxin |
| NCBI Official Symbol: | NXN |
| NCBI Official Synonym Symbols: | NRX; TRG-4 |
| NCBI Protein Information: | nucleoredoxin |
| UniProt Protein Name: | Nucleoredoxin |
| Protein Family: | Nucleoredoxin |
| UniProt Gene Name: | NXN |
| UniProt Entry Name: | NXN_HUMAN |
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