Name: Anti-NXF1 Antibody (CAB5907)
Brand: Cell Biology Antibodies 15
SKU: CAB5907
Availability: OutOfStock

Antibody Name:	Anti-NXF1 Antibody
Antibody SKU:	CAB5907
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 57-356 of human NXF1 (NP_001074960.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	293T, HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 57-356 of human NXF1 (NP_001074960.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	GDVA MSDA QDGP RVRY NPYT TRPN RRGD TWHD RDRI HVTV RRDR APPE RGGA GTSQ DGTS KNWF KITI PYGR KYDK AWLL SMIQ SKCS VPFT PIEF HYEN TRAQ FFVE DAST ASAL KAVN YKIL DREN RRIS IIIN SSAP PHTI LNEL KPEQ VEQL KLIM SKRY DGSQ QALD LKGL RSDP DLVA QNID VVLN RRSC MAAT LRII EENI PELL SLNL SNNR LYRL DDMS SIVQ KAPN LKIL NLSG NELK SERE LDKI KGLK LEEL WLDG NSLC DTFR DQST YIRS VVAC VSPP GDLH PLGG
Gene ID:	10482
Uniprot:	Q9UBU9
Cellular Location:	Cytoplasm, Nucleus, Nucleus speckle, nucleoplasm
Calculated MW:	40kDa/70kDa
Observed MW:	70kDa

Synonyms:

NXF1, MEX67, TAP

Background:

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
NCBI Summary:	This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UBU9
NCBI GenInfo Identifier:	20139282
NCBI Gene ID:	10482
NCBI Accession:	Q9UBU9.1
UniProt Secondary Accession:	Q9UBU9,Q99799, Q9UQL2, B4E269,
UniProt Related Accession:	Q9UBU9
Molecular Weight:	40,476 Da
NCBI Full Name:	Nuclear RNA export factor 1
NCBI Synonym Full Names:	nuclear RNA export factor 1
NCBI Official Symbol:	NXF1
NCBI Official Synonym Symbols:	TAP; MEX67
NCBI Protein Information:	nuclear RNA export factor 1
UniProt Protein Name:	Nuclear RNA export factor 1
UniProt Synonym Protein Names:	Tip-associated protein; Tip-associating protein; mRNA export factor TAP
Protein Family:	Nuclear RNA export factor
UniProt Gene Name:	NXF1
UniProt Entry Name:	NXF1_HUMAN