| UniProt Protein Function: | Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. |
| NCBI Summary: | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBU9 |
| NCBI GenInfo Identifier: | 20139282 |
| NCBI Gene ID: | 10482 |
| NCBI Accession: | Q9UBU9.1 |
| UniProt Secondary Accession: | Q9UBU9,Q99799, Q9UQL2, B4E269, |
| UniProt Related Accession: | Q9UBU9 |
| Molecular Weight: | 40,476 Da |
| NCBI Full Name: | Nuclear RNA export factor 1 |
| NCBI Synonym Full Names: | nuclear RNA export factor 1 |
| NCBI Official Symbol: | NXF1 |
| NCBI Official Synonym Symbols: | TAP; MEX67 |
| NCBI Protein Information: | nuclear RNA export factor 1 |
| UniProt Protein Name: | Nuclear RNA export factor 1 |
| UniProt Synonym Protein Names: | Tip-associated protein; Tip-associating protein; mRNA export factor TAP |
| Protein Family: | Nuclear RNA export factor |
| UniProt Gene Name: | NXF1 |
| UniProt Entry Name: | NXF1_HUMAN |
