Cell Biology Antibodies 9

Anti-NVL Antibody (CAB3995)

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SKU:
CAB3995
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-NVL Antibody
Antibody SKU:CAB3995
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-520 of human NVL (NP_001230076.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NCI-H460, MCF7, Mouse testis, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 340-520 of human NVL (NP_001230076.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CLGI PDEA SRER ILQT LCRK LRLP QAFD FCHL AHLT PGFV GADL MALC REAA MCAV NRVL MKLQ EQQK KNPE MEDL PSKG VQEE RLGT EPTS ETQD ELQR LLGL LRDQ DPLS EEQM QGLC IELN DFIV ALSS VQPS AKRE GFVT VPNV TWAD IGAL EDIR EELT MAIL APVR NPDQ FKAL G
Gene ID:4931
Uniprot:O15381
Cellular Location:Nucleus, nucleolus, nucleoplasm
Calculated MW:72kDa/73kDa/82kDa/85kDa/95kDa
Observed MW:110kDa
Synonyms:NVL, NVL2
Background:This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin.
UniProt Protein Function:NVL: a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 1q41-q42.2

Cellular Component: mitochondrion; membrane; cytoplasm; nucleolus; plasma membrane; nucleus

Molecular Function:ATP binding

NCBI Summary:This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
UniProt Code:O15381
NCBI GenInfo Identifier:32699415
NCBI Gene ID:4931
NCBI Accession:O15381.1
UniProt Secondary Accession:O15381,Q96EM7, B4DMC4, B4DP98,
UniProt Related Accession:O15381
Molecular Weight:856
NCBI Full Name:Nuclear valosin-containing protein-like
NCBI Synonym Full Names:nuclear VCP-like
NCBI Official Symbol:NVL  
NCBI Protein Information:nuclear valosin-containing protein-like; NVLp
UniProt Protein Name:Nuclear valosin-containing protein-like
Protein Family:Nuclear valosin-containing protein
UniProt Gene Name:NVL  
UniProt Entry Name:NVL_HUMAN
Anti-NVL Antibody (CAB3995)Western blot analysis of extracts of various cell lines, using NVL antibody (CAB3995) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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