Epigenetics & Nuclear Signaling Antibodies 4

Anti-NUTF2 Antibody (CAB7057)

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SKU:
CAB7057
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NUTF2 Antibody
Antibody SKU:CAB7057
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human NUTF2 (NP_005787.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human NUTF2 (NP_005787.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGDK PIWE QIGS SFIQ HYYQ LFDN DRTQ LGAI YIDA SCLT WEGQ QFQG KAAI VEKL SSLP FQKI QHSI TAQD HQPT PDSC IISM VVGQ LKAD EDPI MGFH QMFL LKNI NDAW VCTN DMFR LALH NFG
Gene ID:10204
Uniprot:P61970
Cellular Location:Cytoplasm
Calculated MW:14kDa
Observed MW:15kDa
Synonyms:NUTF2, NTF-2, NTF2, PP15
Background:This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62.
UniProt Protein Function:NUTF2: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. Homodimer.
UniProt Protein Details:

Protein type:Nuclear import

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytosol; nuclear outer membrane; nuclear pore

Molecular Function:protein binding; Ran GTPase binding; transporter activity

Biological Process: positive regulation of protein import into nucleus; protein export from nucleus; protein import into nucleus, translocation

NCBI Summary:This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
UniProt Code:P61970
NCBI GenInfo Identifier:48429030
NCBI Gene ID:10204
NCBI Accession:P61970.1
UniProt Secondary Accession:P61970,P13662, Q6IB67, B2R4G7,
UniProt Related Accession:P61970
Molecular Weight:14,478 Da
NCBI Full Name:Nuclear transport factor 2
NCBI Synonym Full Names:nuclear transport factor 2
NCBI Official Symbol:NUTF2  
NCBI Official Synonym Symbols:NTF2; PP15; NTF-2  
NCBI Protein Information:nuclear transport factor 2
UniProt Protein Name:Nuclear transport factor 2
UniProt Synonym Protein Names:Placental protein 15; PP15
UniProt Gene Name:NUTF2  
UniProt Entry Name:NTF2_HUMAN
Anti-NUTF2 Antibody (CAB7057)Western blot analysis of extracts of various cell lines, using NUTF2 antibody (CAB7057) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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