Epigenetics & Nuclear Signaling Antibodies 3

Anti-NUP93 Antibody (CAB4333)

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SKU:
CAB4333
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-NUP93 Antibody
Antibody SKU:CAB4333
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 670-819 of human NUP93 (NP_055484.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, A-431, LO2, HeLa, Mouse brain, Mouse heart, Mouse kidney, Mouse liver, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 670-819 of human NUP93 (NP_055484.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IAER YRAQ GISA NKFV DSTF YLLL DLIT FFDE YHSG HIDR AFDI IERL KLVP LNQE SVEE RVAA FRNF SDEI RHNL SEVL LATM NILF TQFK RLKG TSPS SSSR PQRV IEDR DSQL RSQA RTLI TFAG MIPY RTSG DTNA RLVQ MEVL MN
Gene ID:9688
Uniprot:Q8N1F7
Cellular Location:Nucleus, Nucleus membrane, Peripheral membrane protein, nuclear pore complex
Calculated MW:79kDa/93kDa
Observed MW:93kDa
Synonyms:NUP93, NIC96, NPHS12
Background:The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:NUP93: a nuclear pore protein (nucleoporin) required for correct nuclear pore assembly. The nuclear pore complex, comprised of approximately 30 nucleoporins, mediates the exchange of macromolecules across the nuclear envelope. It is comprised of approximately 30 proteins termed nucleoporins that are each present in multiple copies. Belongs to the nucleoporin interacting component (NIC) family.
UniProt Protein Details:

Protein type:Nucleoporin

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: membrane; nuclear envelope; nuclear membrane; nuclear pore

Molecular Function:structural constituent of nuclear pore

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; nuclear pore complex assembly; poly(A)+ mRNA export from nucleus; positive regulation of defense response to virus by host; protein import into nucleus; protein sumoylation; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription

UniProt Code:Q8N1F7
NCBI GenInfo Identifier:116242684
NCBI Gene ID:9688
NCBI Accession:Q8N1F7.2
UniProt Secondary Accession:Q8N1F7,Q14705, B3KPQ8,
UniProt Related Accession:Q8N1F7
Molecular Weight:79,882 Da
NCBI Full Name:Nuclear pore complex protein Nup93
NCBI Synonym Full Names:nucleoporin 93
NCBI Official Symbol:NUP93  
NCBI Official Synonym Symbols:NIC96; NPHS12  
NCBI Protein Information:nuclear pore complex protein Nup93
UniProt Protein Name:Nuclear pore complex protein Nup93
UniProt Synonym Protein Names:93 kDa nucleoporin; Nucleoporin Nup93
Protein Family:Nuclear pore complex protein
UniProt Gene Name:NUP93  
UniProt Entry Name:NUP93_HUMAN
Anti-NUP93 Antibody (CAB4333)Western blot analysis of extracts of various cell lines, using NUP93 antibody (CAB4333) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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