Cell Cycle Antibodies 1

Anti-NUP43 Antibody (CAB15983)

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SKU:
CAB15983
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-NUP43 Antibody
Antibody SKU:CAB15983
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 150-260 of human NUP43 (NP_942590.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:OVCAR3, HeLa, Rat spleen , Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 150-260 of human NUP43 (NP_942590.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DGRI NLFR ADHK EAVR TIDN ADSS TLHA VTFL RTPE ILTV NSIG QLKI WDFR QQGN EPSQ ILSL TGDR VPLH CVDR HPNQ QHVV ATGG QDGM LSIW DVRQ GTMP VSLL KAH
Gene ID:348995
Uniprot:Q8NFH3
Cellular Location:Chromosome, Nucleus, centromere, kinetochore, nuclear pore complex
Calculated MW:31kDa/42kDa
Observed MW:42kDa
Synonyms:NUP43, bA350J20.1, p42
Background:Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).
UniProt Protein Function:NUP43: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
UniProt Protein Details:

Protein type:Cell cycle regulation; Nucleoporin

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytosol; kinetochore; nuclear envelope

Molecular Function:protein binding

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; protein sumoylation; RNA-mediated gene silencing; sister chromatid cohesion; tRNA export from nucleus; viral reproduction; viral transcription

NCBI Summary:Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
UniProt Code:Q8NFH3
NCBI GenInfo Identifier:27923819
NCBI Gene ID:348995
NCBI Accession:Q8NFH3.1
UniProt Secondary Accession:Q8NFH3,Q9H8S0, B4E2F0,
UniProt Related Accession:Q8NFH3
Molecular Weight:31,512 Da
NCBI Full Name:Nucleoporin Nup43
NCBI Synonym Full Names:nucleoporin 43
NCBI Official Symbol:NUP43  
NCBI Official Synonym Symbols:p42; bA350J20.1  
NCBI Protein Information:nucleoporin Nup43
UniProt Protein Name:Nucleoporin Nup43
UniProt Synonym Protein Names:Nup107-160 subcomplex subunit Nup43; p42
Protein Family:Nucleoporin
UniProt Gene Name:NUP43  
UniProt Entry Name:NUP43_HUMAN
Anti-NUP43 Antibody (CAB15983)Western blot analysis of extracts of various cell lines, using NUP43 antibody (CAB15983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
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