Neuroscience

Anti-NUMBL Antibody (CAB2140)

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SKU:
CAB2140
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Neuroscience

Description

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Antibody Name:Anti-NUMBL Antibody
Antibody SKU:CAB2140
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse Kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPST LQRR TDFQ VKGT VPEM EPPG AGDS DSIN ALCT QISS SFAS AGAP APGP PPAT TGTS AWGE PSVP PAAA FQPG HKRT PSEA ERWL EEVS QVAK AQQQ QQQQ QQQQ QQQQ QQQQ QAAS VAPV PTMP PALQ PFPA PVGP FDAA PAQV AVFL PPPH MQPP FVPA YPGL GYPP MPRV PVVG ITPS QMVA NAFC SAAQ LQPQ PATL LGKA GAFP PPAI PSAP GSQA RPRP NGAP WPPE PAPA PAPE LDPF EAQW AALE GKAT VEKP SNPF SGDL QKTF EIEL
Gene ID:9253
Uniprot:Q9Y6R0
Cellular Location:Cytoplasm
Calculated MW:64kDa
Observed MW:65kDa
Synonyms:NUMBL, CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Background:
UniProt Protein Function:NUMBL: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. Interacts (via PTB domain) with MAP3K7IP2 (via C- terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.
UniProt Protein Details:

Protein type:Cell development/differentiation

Chromosomal Location of Human Ortholog: 19q13.13-q13.2

Cellular Component: cytoplasm

Molecular Function:protein binding

Biological Process: nervous system development; positive regulation of neurogenesis; axonogenesis; cytokine and chemokine mediated signaling pathway; protein metabolic process; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development

UniProt Code:Q9Y6R0
NCBI GenInfo Identifier:14194976
NCBI Gene ID:9253
NCBI Accession:Q9Y6R0.1
UniProt Secondary Accession:Q9Y6R0,Q7Z4J9,
UniProt Related Accession:Q9Y6R0
Molecular Weight:609
NCBI Full Name:Numb-like protein
NCBI Synonym Full Names:numb homolog (Drosophila)-like
NCBI Official Symbol:NUMBL  
NCBI Official Synonym Symbols:NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE  
NCBI Protein Information:numb-like protein; numb homolog-like; numb-related protein
UniProt Protein Name:Numb-like protein
UniProt Synonym Protein Names:Numb-related protein; Numb-R
Protein Family:Numb-like protein
UniProt Gene Name:NUMBL  
UniProt Entry Name:NUMBL_HUMAN
Anti-NUMBL Antibody (CAB2140)Western blot analysis of extracts of Mouse kidney cells, using NUMBL antibody (CAB2140). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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